LOW CIRCULATING THYMULIN-LIKE ACTIVITY IN CHILDREN WITH AIDS AND AIDS-RELATED COMPLEX
LOW CIRCULATING THYMULIN-LIKE ACTIVITY IN CHILDREN WITH AIDS AND AIDS-RELATED COMPLEX
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DOI：
10.1089/aid.1.1986.2.109
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发表时间：
1986-03-01
期刊：
影响因子：
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通讯作者：
FIKRIG, S
中科院分区：
文献类型：
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作者：
INCEFY, GS;PAHWA, S;FIKRIG, S
通过测定21例HTLV-III/LAV逆转录病毒感染的儿科患者血浆中循环胸腺肽样活性水平来评估胸腺分泌功能。所有患者的血清抗体对HTLV-III的p41抗原的蛋白质印迹分析。根据疾病控制中心的最新定义，14名患者患有获得性免疫缺陷综合征（艾滋病），其余7名患者被归类为艾滋病相关综合征。他们的年龄从1岁到7岁不等，其中10人不到1岁。循环胸腺素活性通常在15岁以下的健康儿童中最高，在11名患者中检测不到，其余患者低于正常年龄范围。大多数患者外周血T细胞亚群OKT 4/OKT 8比值低于正常。我们的研究结果表明，胸腺上皮损伤可能是HTLV-III/LAV相关疾病的早期事件，可能先于临床和/或免疫学畸变的发展。
Thymic secretory function was assessed by determining levels of circulating thymulin-like activity in plasma of 21 pediatric patients infected with the HTLV-III/LAV retrovirus. All the patients had serum antibodies against p41 antigens of HTLV-III on Western blot analyses. In accordance with the latest definition established by the Centers for Disease Control, 14 patients had the acquired immunodeficiency syndrome (AIDS) and the remaining 7 were classified as having AIDS-related complex. Their ages ranged from 1 to 7 years, with 10 being less than 1 year of age. Circulating thymulin activity, normally highest in healthy children under 15 years of age, was undetectable in 11 patients and below normal range for age in the remaining. OKT4/OKT8 ratios of T-cell subsets in peripheral blood were below normal in the majority of patients. Our findings suggest that thymic epithelial injury may be an early event in HTLV-III/LAV-related disease and may precede the development of clinical and/or immunologic aberrations.