Efficient oxidative conversion of aldehydes to 2-substituted oxazolines and oxazines using (diacetoxyiodo)benzene
Efficient oxidative conversion of aldehydes to 2-substituted oxazolines and oxazines using (diacetoxyiodo)benzene
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DOI：
10.1055/s-2007-982571
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发表时间：
2007-07-24
期刊：
影响因子：
2
通讯作者：
Gampawar, Sumit V.
中科院分区：
文献类型：
--
作者：
Karade, Nandkishor N.;Tiwari, Girdharilal B.;Gampawar, Sumit V.
报道了以二乙酰氧基碘代苯为氧化剂，由醛和2-氨基醇合成2-取代恶唑啉的方法。（二乙酰氧基碘）苯用作温和的乳化剂以将最初形成的恶唑烷从醛和2-氨基醇转化为2-取代的恶唑啉。类似地，3-氨基丙醇和醛得到相应的2-取代恶嗪。
An efficient synthesis of 2-substituted oxazolines from aldehydes and 2-amino alcohol using (diacetoxyiodo)benzene as an oxidant, is reported. (Diacetoxyiodo)benzene acts as a mild dehydrogenating agent to convert the initially formed oxazolidine from aldehyde and 2-amino alcohol to furnish 2-substituted oxazoline. Similarly, 3-aminopropanol and aldehydes gives the corresponding 2-substituted oxazines.