Association between diabetes complications and leukocyte counts in Iranian patients
Association between diabetes complications and leukocyte counts in Iranian patients
复制标题
DOI：
10.2147/jir.s26917
复制
发表时间：
2012-01-01
影响因子：
4.5
通讯作者：
Salari, Fereshteh
中科院分区：
文献类型：
--
作者：
Moradi, Sedigheh;Kerman, Scott Reza Jafarian;Salari, Fereshteh
背景：糖尿病的长期并发症可能是致命的。它们还以成为经济负担而闻名。以前的研究已经证明了炎症标志物与糖尿病并发症之间的关系。这项研究的目的是评估白细胞计数与这些并发症的关系。方法：该研究包括184名确诊为2型糖尿病的患者。这项研究是2007年至2008年在伊朗进行的。收集的数据如下：年龄、性别、体重、身高、血压、吸烟史、血脂谱(包括低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、总胆固醇、甘油三酯和白细胞计数)、蛋白尿和视网膜病变。此外，还收集了100名患者的心脏病史信息。按白细胞水平分为低白细胞组(7000/mm，3例)和低白细胞组(7000/mm，3例)，分别进行t检验或Mann-Whitney U检验。结果：平均白细胞数为7594±1965/mm(3例)。有无视网膜病变和蛋白尿的患者的白细胞计数有显著差异(P<；0.0001)。根据这一分析，白细胞计数为6750/mm(3)，敏感性为80.2%，特异性为56.4%；计数为7550/mm(3)，敏感性为63.2%，特异性为74.6%，提示至少有一种糖尿病并发症。结论：即使在正常范围，白细胞计数升高也与2型糖尿病慢性并发症有关。
Background: The long term complications of diabetes can be fatal. They are also renowned for being an economic burden. Previous studies have demonstrated a relationship between inflammatory markers and complications of diabetes. The objective of this study was to evaluate the relationship between leukocyte counts and these complications.Methods: The study included 184 patients diagnosed with type 2 diabetes. The study was carried out in Iran during 2007 and 2008. Data collected on the subjects were as follows: age, gender, weight, height, blood pressure, smoking history, lipid profile including low density lipoprotein (LDL), high density lipoprotein (HDL), total cholesterol, triglycerides, and leukocyte count, albuminuria, and retinopathy. Furthermore, information on cardiac history for 100 patients was collected. The subjects were split into two groups according to their leukocyte levels: low ( 7000/mm(3)); and then analyzed by Student's t-test or Mann-Whitney U-test as appropriate.Results: The average leukocyte count in these patients was 7594 +/- 1965/mm(3). Leukocyte count was significantly different in patients with and without retinopathy and albuminuria (P < 0.0001). According to this analysis, a leukocyte count of 6750/mm(3) with a sensitivity of 80.2% and a specificity of 56.4%, and a count of 7550/mm(3) with a sensitivity of 63.2% and a specificity of 74.6% indicated at least one diabetes complication.Conclusion: An elevated leukocyte count even within the normal range was associated with chronic complications in type 2 diabetes.