Stressor controllability modulates stress-induced serotonin but not dopamine efflux in the nucleus accumbens shell
Stressor controllability modulates stress-induced serotonin but not dopamine efflux in the nucleus accumbens shell
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DOI：
10.1002/syn.10229
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发表时间：
2003-09-01
期刊：
影响因子：
2.3
通讯作者：
Maier, SF
中科院分区：
文献类型：
--
作者：
Bland, ST;Twining, C;Maier, SF
生物体控制应激源的能力可以调节压力的许多后果。先前的研究表明，不可控应激(不可逃避休克，IS)激活中缝背核(DRN)5-羟色胺(5-HT)能神经元的程度大于可控应激(Escable Shock，ES)，从而增强DRN和靶区的5-羟色胺(5-HT)外流。先前的研究也表明，IS选择性地影响多巴胺(DA)的外流。本研究采用在体微透析法测定了IS或ES时NAC壳内5-羟色胺和多巴胺的外流。雄性SD大鼠在NAC壳内插入探头，在100 mA、1.0 mA的尾部电击下透析。大鼠在轮子翻转的盒子里成对运行，这样一对大鼠中的一只(ES)可以通过行为反应来终止自己和他的轭(IS)伴侣所受到的电击。透析碗中没有留下压力控制。5-羟色胺流出在应激过程中选择性地增加，并在应激过程中始终保持增加。应激对DA外流无明显影响。这些结果表明，NAc的5-羟色胺反应对应激反应是优先敏感的，并可受应激源可控性的调节。(C)2003年Wiley-Liss，Inc.
The ability of an organism to control a stressor can modulate many of the consequences of stress. Previous research indicates that uncontrollable stress (inescapable shock, IS) activates serotonergic (5-HT) neurons of the dorsal raphe nucleus (DRN) to a greater degree than controllable stress (escapable shock, ES), potentiating 5-HT efflux in the DRN and in target regions. Previous research also indicates that IS selectively affects dopamine (DA) efflux. The present study measured 5-HT and DA efflux in the NAc shell during IS or ES using in vivo microdialysis. Male Sprague Dawley rats with probes in the NAc shell were dialysed while subjected to 100 1.0 mA tailshocks. Rats were run in yoked pairs in wheel-turn boxes such that one rat (ES) in the pair could terminate the shock received by both himself and his yoked (IS) partner by a behavioral response. No stress controls remained in the dialysis bowls. 5-HT efflux selectively increased during IS, and remained increased throughout as well as after the stress session. There was no effect of stress on DA efflux. These results indicate that the NAc 5-HT response is preferentially sensitive to stress and can be modulated by stressor controllability. (C) 2003 Wiley-Liss, Inc.