The differential effect of hereditary mouse dwarfism on the anterior-pituitary hormones
The differential effect of hereditary mouse dwarfism on the anterior-pituitary hormones
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DOI：
10.1002/ar.1090500108
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发表时间：
1931-07-01
影响因子：
--
通讯作者：
MacDowell, EC
中科院分区：
文献类型：
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作者：
Smith, PE;MacDowell, EC
遗传性侏儒小鼠的残疾与大鼠垂体切除术引起的残疾相似，但生殖系统除外。在雄性侏儒中，与垂体切除的大鼠相反，精子发生发生，形成活动精子。雌性侏儒的生殖系统虽然不如雄性侏儒发达，但比没有垂体的大鼠发达。因此，侏儒的生殖系统状况与大鼠的生殖系统状况形成对比，大鼠的前垂体完全缺失，而这两种类型的其他残疾是相似的。这表明，侏儒的垂体生长激素可能受到抑制，而促性腺激素没有相应的抑制。生物学试验表明，情况确实如此。植入正常未成熟雌性小鼠体内的后一种激素显示，侏儒的垂体中每单位重量腺体的浓度高于正常人。将对生长激素特别敏感的侏儒垂体植入侏儒体内，却不能产生任何生长反应。因此，结果显示高浓度的促性腺激素和生长激素的抑制。这与侏儒所表现出的残疾直接相关。
The disabilities present in hereditary dwarf mice are similar to those induced by hypophysec-tomy in rats, except as regards the reproductive system. In male dwarfs, in contrast to hypophysectomized rats, spermatogenesis takes place, with the formation of motile sperm. In female dwarfs the reproductive system, although not so advanced as in the male, nevertheless is further developed than in pituitariless rats. The condition of the reproductive system in dwarfs thus contrasts with that of rats in which the anterior hypophysis is completely lacking, whereas other disabilities in the two types are similar. This suggested that the pituitary growth hormone in dwarfs might be suppressed without a corresponding suppression of the gonad-stimulating hormone. Biological tests show that such is the case. The latter hormone, as revealed by implants into normal immature female mice, is present in the pituitaries of dwarfs in greater concentration per unit weight of gland than in normals. Implants of dwarf pituitaries into dwarfs[long dash]a form uniquely sensitive to administration of the growth hormone[long dash]failed to give any growth response. The results thus show a high concentration of the gonad-stimulating hormone and a suppression of the growth hormone. This is directly correlated with the disabilities exhibited by the dwarfs.