John W. Daly (1933-2008).
John W. Daly (1933-2008).
复制标题
约翰·戴利 (1933-2008)。
DOI：
10.1021/np1000494
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发表时间：
2010
影响因子：
5.1
通讯作者：
Bewley,CaroleA
中科院分区：
文献类型：
--
作者：
Fitch,RichardW;Bewley,CaroleA
John William Daly was born in Portland, OR, on June 8, 1933. He obtained his BS from Oregon State College in 1954, and his MA the following year with Bert Christensen on the synthesis of purine and pteridine alkaloids. His Ph. D. work was done at Stanford University with Richard Eastman, studying the terpenes of peppermint oil. Upon its completion John accepted an NIH postdoctoral position with Bernhard Witkop in the Laboratory of Chemistry at the National Institute of Arthritis and Metabolic Diseases (NIAMD). John was soon appointed to the permanent staff and became the founding Chief of the NIAMD-derived Laboratory of Bioorganic Chemistry in 1981. He served as LBC Chief (now in NIDDK) until stepping down in 1997 and becoming NIH Scientist Emeritus in 2003. A testament to John’s tireless enthusiasm for solving those scientific problems that still captivated him, he “retired” in 2003 so as to focus more intently on doing research, publishing 45 papers between 2003 and his passing on March 5, 2008. His works continue, with 14 scientific papers published posthumously and more in preparation. In all, John authored or coauthored over 700 papers in chemistry, ecology, and pharmacology, including 22 in the Journal of Natural Products, one a comprehensive review describing over 800 amphibian alkaloids. 1a John was also active in the ASP, serving on numerous committees and on the editorial board for the Journal of Natural Products.The nature of science is collaborative, and John had many collaborators, more names than would fit in this space. These led to some of his most impactful discoveries. The unique environment at NIH served John well, with many experts a short walk from his office. While a postdoctoral fellow, John worked with pharmacologist Julius Axelrod on catecholamines, determining the mechanism of methylation with S-adenosylmethionine. Collaboration with Sidney Udenfriend, Don Jerina, and Gordon Guroff led to the discovery of the “NIH-shift”, a rearrangement in aromatic hydroxylation via an arene oxide. 2 This process is a major pathway in carcinogenesis caused by polycyclic aromatics. Work with Solomon Snyder led to the discovery that caffeine inhibited adenosine receptors and opened up the area of purinergic receptors along with collaborator Kenneth Jacobson. 3
