Ontogeny of the interferon system in chickens
Ontogeny of the interferon system in chickens
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DOI：
10.1016/j.jri.2012.02.008
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发表时间：
2012-06-01
影响因子：
3.4
通讯作者：
Bean, Andrew G. D.
中科院分区：
文献类型：
--
作者：
Karpala, Adam J.;Bagnaud-Baule, Audrey;Bean, Andrew G. D.
新生的脊椎动物可能容易受到感染，因为它们的免疫系统的不成熟状态导致无法做出有效的免疫反应。因此，新孵化的小鸡似乎比成熟的鸡更容易感染。特别是，家禽对病毒感染的易感性可能与参与抗病毒反应的先天免疫元件表达不足有关。因此，在这项研究中，我们评估了干扰素（IFN）系统的相对发展：一种针对病毒感染的保护系统。我们研究了与年龄相关的IFN反应，包括IFN基因的表达，其相关的受体和模式识别受体（PRR）参与IFN的调节元素的表达。我们观察到，IFN系统在胚胎中的表达有些不足，并随着时间的推移而发展，就在孵化之前和之后，因此，由于不成熟的IFN网络，小鸡可能比成熟的鸟类更容易感染病毒。皇冠版权所有（c）2012由爱思唯尔爱尔兰有限公司出版。保留所有权利。
Newborn vertebrates may be susceptible to infection because the immature status of their immune system results in an inability to make an effective immune response. Consequently, newly hatched chicks appear to be more susceptible to infections than mature chickens. In particular, poultry susceptibility to virus infection may be related to poor expression of innate immune elements involved in antiviral responses. Therefore, in this study we assessed the relative development of the interferon (IFN) system: a protective system against virus infection. We investigated the age-related expression of the elements involved in the IFN response including IFN gene expression, their associated receptors and the pattern recognition receptors (PRR) involved in the regulation of IFNs. We observed that the IFN system is somewhat inadequately expressed in embryos and develops over time, just prior to and after hatching, and therefore chicks may be more susceptible to virus than mature birds because of an immature IFN network. Crown Copyright (c) 2012 Published by Elsevier Ireland Ltd. All rights reserved.