Effect of increased body mass index on oocyte and embryo quality in IVF patients
Effect of increased body mass index on oocyte and embryo quality in IVF patients
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DOI：
10.1016/s1472-6483(10)60385-9
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发表时间：
2007-11-01
影响因子：
4
通讯作者：
Li, T. C.
中科院分区：
文献类型：
--
作者：
Metwally, M.;Cutting, R.;Li, T. C.
肥胖可能对IVF/卵胞浆内单精子注射（ICSI）治疗的结果产生不良影响。在这项研究中，体重指数（BMI）增加对卵母细胞和胚胎质量在IVF周期的影响进行了研究。对426个IVF/ICS 1周期进行了回顾性分析。周期根据BMI分类：正常BMI（19-24.9 ka/m2），超重（25-29.9 kg/m2）和肥胖（a30 kg/m2）。根据年龄对周期进行进一步分层（第1组，< 35岁;第2组，35岁）。检测卵母细胞质量（受精卵数和受精率）和胚胎质量（利用率、弃卵数和冻存胚胎数以及平均胚胎等级）。第1组中，肥胖对平均胚胎等级（P = 0.02）、胚胎利用率（P = 0.01）、胚胎弃卵数（P = 0.007）和冷冻保存数（P < 0.05）有显著的不良影响。在第2组中，三个BMI等级之间的胚胎质量标志物没有差异。肥胖对卵母细胞质量或临床妊娠率没有任何显着影响。总之，肥胖可能对接受IVF/ICSI的年轻女性（< 35岁）的胚胎质量产生不利影响，而卵母细胞质量不受影响。
Obesity may have an adverse effect on the outcome of IVF/intracytoplasmic sperm injection (ICSI) treatment. In this study, the effects of increased body mass index (BMI) on oocyte and embryo quality during IVF cycles were studied. A retrospective analysis of 426 IVF/ICSl cycles was performed. Cycles were classified according to the BMI: normal BMI (19-24.9 ka/m(2)), overweight (25-29.9 kg/m(2)) and obese (a30 kg/m(2)). Cycles were further stratified based on age (group 1, < 35 years; group 2, 35 years). Markers of oocyte quality (number of oocytes inseminated and fertilization rate) and embryo quality (utilization rate, number of embryos discarded and cryopreserved, and mean embryo grade) were examined. In group 1, obesity had a significant adverse effect on the mean embryo grade (P = 0.02), the embryo utilization rate (P = 0.01), number of embryos discarded (P = 0.007) and cryopreserved (P < 0.05). In group 2, there was no difference in markers of embryo quality between the three BMI ranks. Obesity did not have any significant effect on markers of oocyte quality or clinical pregnancy rates. In conclusion, obesity may adversely affect embryo quality in young women (< 35 years) undergoing IVF/ICSI, while the oocyte quality is not affected.