Enhanced metabolic efficiency contributes to weight regain after weight loss in obesity-prone rats
Enhanced metabolic efficiency contributes to weight regain after weight loss in obesity-prone rats
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DOI：
10.1152/ajpregu.00463.2004
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发表时间：
2004-12-01
影响因子：
2.8
通讯作者：
Hill, JO
中科院分区：
文献类型：
--
作者：
MacLean, PS;Higgins, JA;Hill, JO
随着体重的减少，新陈代谢的调整可能会导致高的体重恢复率。我们之前在肥胖倾向的肥胖大鼠中观察到，体重减轻伴随着静息代谢率的抑制，这超出了代谢质量变化的预测。在目前的研究中，我们研究了这种代谢效率的调整是否受到体重维持时间长短的影响，以及它是否有助于减肥后恢复的倾向。通过间接量热法获得24小时、非静息和静息能量消耗（REE），并将其归一化为双能X射线吸收仪估计的代谢质量。体重减轻的大鼠体重减轻10%时，调整后的REE抑制15%。这种代谢效率的提高在维持体重8周或16周后都没有改变，但当强行控制摄入并恢复体重时，代谢效率的提高确实消失了。体重恢复率随体重维持时间的延长而增加，在复发期早期异常高。在这种高体重增加的过程中，REE的抑制持续存在，而摄入量增加到比肥胖时更高的水平。总之，代谢效率的提高和食欲的增加都导致了（分别为60%和40%）巨大的潜在能量失衡，当对能量摄入的强制控制解除时，这种失衡就会实现，并导致异常高的体重恢复率。
Metabolic adjustments occur with weight loss that may contribute to a high rate of weight regain. We have previously observed in obesity-prone, obese rats that weight reduction is accompanied by a suppression in resting metabolic rate beyond what would be predicted for the change in metabolic mass. In the present study, we examine if this adjustment in metabolic efficiency is affected by the length of time in weight maintenance and if it contributes to the propensity to regain after weight loss. Twenty- four- hour, nonresting, and resting energy expenditure ( REE) were obtained by indirect calorimetry and normalized to metabolic mass estimated by dual- energy X- ray absorptiometry. A 10% loss in body weight in weight- reduced rats was accompanied by a 15% suppression in adjusted REE. This enhancement in metabolic efficiency was not altered with either 8 or 16 wk of weight maintenance, but it did resolve when the forced control of intake was removed and the weight was regained. The rate of weight regain increased with the time in weight maintenance and was exceptionally high early during the relapse period. During this high rate of weight gain, the suppression in REE persists while consumption increases to a level that is higher than when they were obese. In summary, an enhanced metabolic efficiency and an elevated appetite both contribute ( 60% and 40%, respectively) to a large potential energy imbalance that, when the forcible control of energy intake is relieved, becomes actualized and results in an exceptionally high rate of weight regain.