On the validity of the TDT test in the presence of comorbidity and ascertainment bias
On the validity of the TDT test in the presence of comorbidity and ascertainment bias
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DOI：
10.1002/gepi.1038
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发表时间：
2001-12-01
影响因子：
2.1
通讯作者：
Lunetta, KL
中科院分区：
文献类型：
--
作者：
Robins, JM;Smoller, JW;Lunetta, KL
合并症是两种疾病的关联，通常发生在复杂疾病中。在本文中。我们研究了真实（家庭内）合并症和由于确定偏差而导致的虚假合并症对父母和兄弟姐妹控制传播/不平衡测试有效性的影响。具体来说。我们考虑这样的情况：候选基因与目标表型不相关，但与共病表型连锁不平衡。我们推导出真实和/或虚假合并症的存在将导致目标表型和候选基因之间人为相关的条件。 (C) 2001 年威利利斯。公司
Comorbidity, the association of two disorders, occurs commonly with complex diseases. In this paper. we investigate the effects of both true (within-family) comorbidity and spurious comorbidity due to ascertainment bias on the validity of both the parental and sibling control transmission/disequilibrium test. Specifically. we consider settings in which a candidate gene is unlinked to the target phenotype but is in linkage disequilibrium with a comorbid phenotype. We derive conditions under which the presence of true and/or spurious comorbidity will result in an artificial correlation between the target phenotype and the candidate gene. (C) 2001 Wiley-Liss. Inc.