Physical and clinical performance of the mCT time-of-flight PET/CT scanner
Physical and clinical performance of the mCT time-of-flight PET/CT scanner
复制标题
DOI：
10.1088/0031-9155/56/8/004
复制
发表时间：
2011-04-21
影响因子：
3.5
通讯作者：
Townsend, D. W.
中科院分区：
文献类型：
--
作者：
Jakoby, B. W.;Bercier, Y.;Townsend, D. W.
飞行时间（TOF）测量能力有望提高PET图像质量。我们表征了第一台Biograph mCT TOF PET/CT扫描仪（Siemens Medical Solutions USA，Inc.）的物理和临床PET性能。与其前身Biograph TruePoint TrueV相比，特别是，我们定义了TOF的改进。根据美国电气制造商协会（NEMA）NU 2-2007标准评估物理性能，并进行额外测量以专门解决TOF能力。分析患者数据以获得扫描仪的临床性能。正如相同尺寸晶体探测器的预期，在mCT上测量的空间分辨率与TruePoint TrueV相似。mCT显示出适度更高的灵敏度（增加19.7 +/- 2.8%）和峰值噪声等效计数率（NECR）（增加15.5 +/- 5.7%），散射分数相似。对于高达55 Mcps的不同单次计数率，能量、时间和空间分辨率分别为11.5 +/- 0.2%（FWHM）、527.5 +/- 4.9 ps（FWHM）和4.1 +/- 0.0 mm（FWHM）。随着TOF的增加，mCT还在临床相关体模几何结构中产生了显著更高的图像对比度恢复和信噪比。TOF的益处在代表性患者图像中得到了明确证明。
Time-of-flight (TOF) measurement capability promises to improve PET image quality. We characterized the physical and clinical PET performance of the first Biograph mCT TOF PET/CT scanner (Siemens Medical Solutions USA, Inc.) in comparison with its predecessor, the Biograph TruePoint TrueV. In particular, we defined the improvements with TOF. The physical performance was evaluated according to the National Electrical Manufacturers Association (NEMA) NU 2-2007 standard with additional measurements to specifically address the TOF capability. Patient data were analyzed to obtain the clinical performance of the scanner. As expected for the same size crystal detectors, a similar spatial resolution was measured on the mCT as on the TruePoint TrueV. The mCT demonstrated modestly higher sensitivity (increase by 19.7 +/- 2.8%) and peak noise equivalent count rate (NECR) (increase by 15.5 +/- 5.7%) with similar scatter fractions. The energy, time and spatial resolutions for a varying single count rate of up to 55 Mcps resulted in 11.5 +/- 0.2% (FWHM), 527.5 +/- 4.9 ps (FWHM) and 4.1 +/- 0.0 mm (FWHM), respectively. With the addition of TOF, the mCT also produced substantially higher image contrast recovery and signal-to-noise ratios in a clinically-relevant phantom geometry. The benefits of TOF were clearly demonstrated in representative patient images.