Calixarene ionic liquid modified silica gel: A novel stationary phase for mixed-mode chromatography
Calixarene ionic liquid modified silica gel: A novel stationary phase for mixed-mode chromatography
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杯芳烃离子液体改性硅胶：一种用于混合模式色谱的新型固定相
DOI：
10.1016/j.talanta.2016.02.038
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发表时间：
2016-05-15
期刊：
影响因子：
6.1
通讯作者：
Zhang, Shusheng
中科院分区：
文献类型：
--
作者：
Hu, Kai;Zhang, Wenfen;Zhang, Shusheng
通过制备新型杯芳烃单体并将其接枝于巯丙基改性硅胶上，合成了新型杯芳烃离子液体功能化二氧化硅材料。通过红外光谱、元素分析和热重分析对该材料进行了表征。为了探索固定相的保留机制，使用线性溶剂化能量关系（LSER）方程作为有效的数学模型。除此之外，还通过不同模式下的色谱分离的选定示例概述了不同的分离机制。在反相液相色谱中，当使用烷基苯、多环芳烃和酚类作为溶质进行评估时，这种新型固定相呈现出特定的色谱性能。由于存在极性官能团，该固定相还可用于亲水相互作用色谱，在亲水模式下成功分离了六种核苷和四种人参皂苷。此外，阴离子可以在阴离子交换模式下在柱上分离。因此，这种新材料可以作为液相色谱中的一种新型混合模式固定相，通过调整实验条件可以非常灵活地调整保留和选择性。 (C) 2016 Elsevier B.V. 保留所有权利。
A novel calixarene ionic liquid functionalized silica material was synthesized by the preparation of a new calixarene monomer and its grafting on mercaptopropyl modified silica gel. The material was characterized by infrared spectra, elemental analysis, and thermogravimetric analysis. To explore the retention mechanism of the stationary phase, linear solvation energy relationships (LSER) equation as an effective mathematical model was used. In addition to this, the distinct separation mechanisms were outlined by selected examples of chromatographic separations in the different modes. In reversed-phase liquid chromatography, this new stationary phase presented specific chromatographic performance when evaluated using alkylbenzenes, PAHs and phenols as solutes. Due to the existing polar functional groups, this stationary phase can also be used in hydrophilic interaction chromatography, six nucleosides and four ginsenosides were separated successfully in hydrophilic mode. Furthermore, anions can be separated on the column in anion exchange mode. Thus, this new material was can be applied as a new kind of mixed-mode stationary phase in liquid chromatography, which allows an exceptionally flexible adjustment of retention and selectivity by tuning the experimental conditions. (C) 2016 Elsevier B.V. All rights reserved.