The response regulator SprE controls the stability of RpoS.
The response regulator SprE controls the stability of RpoS.
复制标题
响应调节器 SprE 控制 RpoS 的稳定性。
DOI：
10.1073/pnas.93.6.2488
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发表时间：
1996
影响因子：
11.1
通讯作者：
Silhavy,TJ
中科院分区：
文献类型：
--
作者：
Pratt,LA;Silhavy,TJ
在大肠杆菌中，σ因子RpoS是稳定期细胞中的中心调节因子。我们已经确定了一个基因，sprE（静止相调节器），作为必不可少的负调控rpoS表达。SprE在蛋白质稳定性水平上负调控rpoS基因产物，这可能是对营养可用性的响应。SprE使RpoS不稳定的能力取决于ClpX/ClpP蛋白酶。基于同源性，SprE是反应调节蛋白家族的成员。SprE是第一个被鉴定的参与蛋白质稳定性控制的反应调节剂。此外，SprE是第一个报道的蛋白质，似乎调节rpoS响应于特定的环境参数。
In Escherichia coli, the sigma factor, RpoS, is a central regulator in stationary-phase cells. We have identified a gene, sprE (stationary-phase regulator), as essential for the negative regulation of rpoS expression. SprE negatively regulates the rpoS gene product at the level of protein stability, perhaps in response to nutrient availability. The ability of SprE to destabilize RpoS is dependent on the ClpX/ClpP protease. Based on homology, SprE is a member of the response regulator family of proteins. SprE is the first response regulator identified that is implicated in the control of protein stability. Moreover, SprE is the first reported protein that appears to regulate rpoS in response to a specific environmental parameter.