MicroRNA: a new and promising potential biomarker for diagnosis and prognosis of ovarian cancer.
MicroRNA: a new and promising potential biomarker for diagnosis and prognosis of ovarian cancer.
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DOI：
10.7497/j.issn.2095-3941.2015.0024
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发表时间：
2015-12
影响因子：
5.5
通讯作者：
Sankhwar P
中科院分区：
文献类型：
--
作者：
Pal MK;Jaiswar SP;Dwivedi VN;Tripathi AK;Dwivedi A;Sankhwar P
上皮性卵巢癌（EOC）是所有妇科恶性肿瘤中导致死亡的主要原因。尽管在过去四十年中技术和医学取得了进步，例如几种生物标志物（mRNA和蛋白质生物标志物）的发展，但卵巢癌的死亡率仍然是一个挑战，因为它的诊断较晚，这特别归因于低特异性和敏感性。在这种强迫性的情况下，最近表达生物学的进展已经转移到识别和开发特异性和敏感的生物标志物，如用于癌症诊断和预后的microRNAs （miRNAs）。mirna是一类新型的小非编码rna，通过翻译抑制或mRNA降解在转录后水平上解除基因表达的调控。这些机制可能涉及与许多类型癌症的病理生理相关的复杂级联细胞事件。mirna很容易在癌症患者的组织和血液样本中检测到。因此，mirna作为卵巢癌的潜在生物标志物具有良好的前景。在这篇综述中，我们试图提供与卵巢癌相关的关键mirna的全面描述，以建立mirna作为卵巢癌早期检测的更可靠的非侵入性临床生物标志物，而不是蛋白质和DNA生物标志物。
Epithelial ovarian cancer (EOC) is the leading cause of death among all gynecological malignancies. Despite the technological and medical advances over the past four decades, such as the development of several biological markers (mRNA and proteins biomarkers), the mortality rate of ovarian cancer remains a challenge because of its late diagnosis, which is specifically attributed to low specificities and sensitivities. Under this compulsive scenario, recent advances in expression biology have shifted in identifying and developing specific and sensitive biomarkers, such as microRNAs (miRNAs) for cancer diagnosis and prognosis. MiRNAs are a novel class of small non-coding RNAs that deregulate gene expression at the posttranscriptional level, either by translational repression or by mRNA degradation. These mechanisms may be involved in a complex cascade of cellular events associated with the pathophysiology of many types of cancer. MiRNAs are easily detectable in tissue and blood samples of cancer patients. Therefore, miRNAs hold good promise as potential biomarkers in ovarian cancer. In this review, we attempted to provide a comprehensive profile of key miRNAs involved in ovarian carcinoma to establish miRNAs as more reliable non-invasive clinical biomarkers for early detection of ovarian cancer compared with protein and DNA biomarkers.