Anti-schistosome IgG4 and IgE at 2 years after chemotherapy: Infected versus uninfected individuals
Anti-schistosome IgG4 and IgE at 2 years after chemotherapy: Infected versus uninfected individuals
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DOI：
10.1086/514131
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发表时间：
1997-11-01
影响因子：
6.4
通讯作者：
Yazdanbakhsh, M
中科院分区：
文献类型：
--
作者：
Grogan, JL;Kremsner, PG;Yazdanbakhsh, M
对某血吸虫病流行地区37例曾感染血血吸虫，化疗后2年未感染或再次感染的患者，进行了IgG4和IgE对成虫抗原（AWA）和可溶性卵抗原（SEA）的特异性反应检测。再感染组明显年轻（中位年龄11岁），明显低于未感染组（中位年龄24岁）。治疗后IgG4对卵抗原（IgG4- sea）水平与再感染强度显著相关（r = 0.74, P < 0.0001），未感染组IgG4- sea水平较再感染组低13倍。虽然治疗后IgE与AWA和SEA之间没有相关性，但治疗前IgE-AWA与再感染水平呈负相关（r = - 0.39, P = .02）。
Specific IgG4 and IgE responses to adult worm antigen (AWA) and soluble egg antigen (SEA) were examined in 37 subjects from an area in which schistosomiasis is endemic, who were previously infected with Schistosoma haematobium and who became reinfected or remained free of infection 2 years after chemotherapy, The reinfected group was significantly younger (median age, 11 years) than the uninfected group (median age, 24 years). Posttreatment levels of IgG4 to egg antigens (IgG4-SEA) were significantly correlated with reinfection intensity (r = .74, P < .0001), and 13-fold lower levels of IgG4-SEA were observed in uninfected subjects compared with reinfected subjects. Although no correlation was observed between posttreatment IgE to AWA or to SEA, pretreatment IgE-AWA was inversely correlated with the level of reinfection (r = -.39, P = .02).