Neurotrophins and the specification of neuronal phenotype
Neurotrophins and the specification of neuronal phenotype
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DOI：
10.1098/rstb.1996.0035
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发表时间：
1996-03-29
期刊：
影响因子：
--
通讯作者：
Lewin, GR
中科院分区：
文献类型：
--
作者：
Lewin, GR
神经生长因子、脑源性神经营养因子和神经营养因子-3都影响背根神经节的感觉神经元。传统上，这些神经营养素被认为是感觉神经元发育过程中的生存因子。最近的证据表明，这些蛋白质的体内水平已被操纵的实验表明，它们可能会影响特定的感觉神经元表型的发展。在这篇综述中，这些实验进行了讨论，神经营养因子可能会影响感觉神经元的表型命运的机制。第一种机制要求，当神经元变得依赖于神经营养因子的存活时，该因子的可用性仅影响以某种方式存活的神经元的数量。该模型要求神经营养因子反应性是神经元可能获得的可能模式的决定因素。第二种机制要求给定神经营养因子的可用性影响多少神经元可以独立于存活分化成不同的感觉神经元表型。现有的实验数据进行了讨论，在这两个模型。
Nerve growth factor, brain derived neurotrophic factor and neurotrophin-3 all influence sensory neurons derived from the dorsal root ganglia. Traditionally these neurotrophins have been thought of as survival factors for sensory neurons during their development. Recent evidence from experiments where the in vivo levels of these proteins has been manipulated indicates that they may influence the development of specific sensory neuron phenotypes. In this review these experiments are discussed in relation to the mechanisms by which neurotrophins could influence the phenotypic fate of sensory neurons. The first mechanism requires that when a neuron becomes dependent for survival on a neurotrophin the availability of the factor simply influences the number of neurons surviving with a certain modality. This model requires that neurotrophin responsiveness is a determinant of the possible modalities that the neuron may acquire. The second mechanism requires that the availability of a given neurotrophin influences how many neurons can differentiate into different sensory neuron phenotype independent of survival. The available experimental data is discussed in relation to these two models.