Direct Observation of the Dynamics of Semiflexible Polymers in Shear Flow
Direct Observation of the Dynamics of Semiflexible Polymers in Shear Flow
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DOI：
10.1103/physrevlett.110.108302
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发表时间：
2013-03-05
影响因子：
8.6
通讯作者：
Bausch, Andreas R.
中科院分区：
文献类型：
--
作者：
Harasim, Markus;Wunderlich, Bernhard;Bausch, Andreas R.
聚合物液体的流动行为可以追溯到剪切流动中聚合物分子的复杂构象动力学，由于固有的大量自由度，这对理论和实验都构成了重大挑战。在这里，我们直接确定的配置动态的单个肌动蛋白丝的长度不同，在一个明确的剪切几何相结合的显微镜，微流体，和半自动移动阶段。这允许识别的微观机制和推导的分析模型的基础上的阻力，弯曲和随机力的平衡个别丝的动态。DOI：10.1103/PhysRevLett.110.108302
The flow behavior of polymeric liquids can be traced back to the complex conformational dynamics of polymer molecules in shear flow, which poses a major challenge to theory and experiment alike due to the inherently large number of degrees of freedom. Here we directly determine the configurational dynamics of individual actin filaments with varying lengths in a well defined shear geometry by combining microscopy, microfluidics, and a semiautomated moving stage. This allows the identification of the microscopic mechanisms and the derivation of an analytical model for the dynamics of individual filaments based on the balance of drag, bending, and stochastic forces. DOI: 10.1103/PhysRevLett.110.108302