Regional changes in sympathetic nerve activity and baroreceptor reflex function and arterial plasma levels of catecholamines, renin and vasopressin during naloxone-precipitated morphine withdrawal in rats.
Regional changes in sympathetic nerve activity and baroreceptor reflex function and arterial plasma levels of catecholamines, renin and vasopressin during naloxone-precipitated morphine withdrawal in rats.
复制标题
纳洛酮促使大鼠吗啡戒断期间交感神经活动和压力感受器反射功能以及儿茶酚胺、肾素和加压素的动脉血浆水平的区域变化。
DOI：
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发表时间：
1990
影响因子：
3.5
通讯作者：
P. Thoren
中科院分区：
文献类型：
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作者：
M. Delle;S. Ricksten;J. Häggendal;K. Olsson;J. Skarphedinsson;P. Thoren
本研究旨在观察氯醛糖麻醉大鼠戒断过程中交感神经活动(SNA)、压力感受器功能及动脉血浆儿茶酚胺、精氨酸加压素(AVP)和肾素活性的变化。依赖是由S.C.吗啡基丸。记录静脉注射前后肾上腺、肾脏和内脏的SNA和腰交感神经链的SNA。注射纳洛酮。用苯肾上腺素引起的平均动脉压升高来检测压力感受器功能。在单独的实验中，测定了纳洛酮催促戒断前后动脉血浆去甲肾上腺素、肾上腺素、多巴胺、血浆肾素活性和AVP。纳洛酮治疗引起平均动脉压和心率的增加。虽然肾脏SNA被抑制了约50%，但肾上腺SNA和腰椎SNA分别增加了约400%和80%。内脏SNA无明显变化。压力感受器对肾上腺SNA的抑制作用增强，而对肾SNA的抑制作用减弱。动脉血浆去甲肾上腺素水平增加了一倍，肾上腺素增加了近20倍。AVP增加了约15倍，而血浆肾素活性在纳洛酮治疗后仅有轻微增加。本研究表明，在吗啡戒断过程中，大鼠的SNA反应发生了明显的分化，这表明阿片受体与区域交感神经输出的控制之间存在相互作用。此外，大量的AVP和肾上腺素被释放，这可能是在戒断阶段看到的心血管变化的原因。
The aim of the study was to examine regional changes in sympathetic nerve activity (SNA) and baroreceptor function and arterial plasma catecholamines, arginine vasopressin (AVP) and plasma renin activity during morphine withdrawal in chloralose-anesthetized rats. Dependence was induced by s.c. morphine base pellets. Adrenal, renal and splanchnic SNA and SNA from the lumbar sympathetic chain were recorded before and after i.v. injections of naloxone. Baroreceptor function was examined with phenylephrine-induced increases in mean arterial pressure. In separate experiments, arterial plasma norepinephrine, epinephrine, dopamine, plasma renin activity and AVP were measured before and after naloxone-precipitated withdrawal. Naloxone administration elicited an increase in mean arterial pressure and heart rate. Although renal SNA was inhibited by approximately 50%, adrenal SNA and lumbar SNA increased by approximately 400 and 80%, respectively. Splanchnic SNA did not change significantly. The baroreceptor-mediated inhibition of adrenal SNA was facilitated while that for renal SNA was attenuated. The arterial plasma level of norepinephrine was doubled and epinephrine increased almost 20-fold. AVP increased about 15-fold, whereas plasma renin activity showed only a minor increase after naloxone. This study shows that a marked differentiation of the SNA response occurs during morphine withdrawal in rats, which suggests an interaction between opioid receptors and the control of regional sympathetic output. Furthermore, large amounts of AVP and epinephrine are released, which probably contribute to the cardiovascular changes seen in the withdrawal phase.