Gray matter increase induced by practice correlates with task-specific activation:: A combined functional and morphometric magnetic resonance Imaging study
Gray matter increase induced by practice correlates with task-specific activation:: A combined functional and morphometric magnetic resonance Imaging study
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DOI：
10.1523/jneurosci.5722-07.2008
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发表时间：
2008-04-16
影响因子：
5.3
通讯作者：
Muehlau, Mark
中科院分区：
文献类型：
--
作者：
Ilg, Ruediger;Wohlschlaeger, Afra M.;Muehlau, Mark
练习引起的灰质增加的神经生理学基础尚不清楚。为了研究练习引起的灰质变化和神经激活之间的关系，我们对镜像阅读进行了纵向功能和形态测量（基于体素的形态测量）磁共振成像（MRI）相结合的研究。与正常阅读相比，镜像阅读导致背外侧枕叶皮层、内侧枕叶皮层、上顶叶皮层、内侧和背外侧前额叶皮层以及前岛叶和小脑的激活。每天练习 15 分钟，持续两周，镜读能力得到提高。在对纯粹的表现影响进行校正后，我们发现与练习相关的右上顶叶皮层的激活减少，而右背枕叶皮层的激活增加。基于纵向体素的形态测量分析显示，右侧背外侧枕叶皮层的灰质增加，这与镜像阅读特异性激活的峰值相对应。这证实了短期灰质信号的增加对应于特定任务的处理。我们推测 MRI 中与实践相关的灰质信号变化主要与特定处理区域内的突触重塑有关。
The neurophysiological basis of practice-induced gray matter increase is unclear. To study the relationship of practice-induced gray matter changes and neural activation, we conducted a combined longitudinal functional and morphometric (voxel-based morphometry) magnetic resonance imaging (MRI) study on mirror reading. Compared with normal reading, mirror reading resulted in an activation of the dorsolateral occipital cortex, medial occipital cortex, superior parietal cortex, medial and dorsolateral prefrontal cortex, as well as anterior insula and cerebellum. Daily practice of 15 min for 2 weeks resulted in an increased performance of mirror reading. After correction for pure performance effects, we found a practice-related decrease of activation at the right superior parietal cortex and increase of activation at the right dorsal occipital cortex. The longitudinal voxel-based morphometry analysis yielded an increase of gray matter in the right dorsolateral occipital cortex that corresponded to the peak of mirror-reading-specific activation. This confirms that short-term gray matter signal increase corresponds to task-specific processing. We speculate that practice-related gray matter signal changes in MRI are primarily related to synaptic remodeling within specific processing areas.