No Association between Tumor Necrosis Factor-alpha Gene Polymorphisms and Lung Cancer Risk.
No Association between Tumor Necrosis Factor-alpha Gene Polymorphisms and Lung Cancer Risk.
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DOI：
10.5620/eht.2013.28.e2013012
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发表时间：
2013
影响因子：
--
通讯作者：
Hong YC
中科院分区：
文献类型：
--
作者：
Kim JH;Hong YC
探讨肿瘤坏死因子-α（TNF-α）基因多态性在肺癌发生中的作用。对616例肺癌患者和616例非肺癌对照者的TNF-α基因多态性进行了分析，其基因型为-1210 C>T、-487 A> G、-417 A>G、IVS 1 + 123 G>A和IVS 3 + 51 A>G。在校正体重指数和吸烟后，每个TNF-α基因型或由5个TNF-α单核苷酸多态性组成的单倍型与肺癌风险无关（p>0.05）。发现1210 C>T、-487 A>G、-417 A> G、IVS 1 + 123 G>A和IVS 3 + 51 A>G的统计功效分别为88.4%、89.3%、93.3%、69.7%和93.9%。此外，未发现每个SNP或单倍型对肺癌风险的影响因肺癌细胞类型而异（p>0.05）。在仅对无其他炎症相关疾病的受试者进行的重复分析中，TNF-α基因的多态性或单倍型与肺癌风险之间也无关联（p>0.05）。这项研究发现TNF-α基因的常见变异与肺癌风险之间没有关联。
The role of genetic polymorphisms of tumor necrosis factor-alpha (TNF-α) for lung cancer development was evaluated. Genotypes of the TNF-α polymorphisms, -1210C>T, -487A>G, -417A>G, IVS1+123G>A, and IVS3+51A>G, were determined in 616 lung cancer cases and 616 lung cancer-free controls. After adjusting for body mass index and smoking, each TNF-α genotype or haplotype composed of five TNF-α single nucleotide polymorphisms did not show an association with lung cancer risk (p>0.05). The statistical power was found to be 88.4%, 89.3%, 93.3%, 69.7%, and 93.9% for 1210C>T, -487A>G, -417A>G, IVS1+123G>A, and IVS3+51A>G, respectively. Furthermore, the effects of each SNP or haplotype on lung cancer risk were not found to be different according to the cell type of lung cancer (p>0.05). In the repeated analysis with only subjects without other diseases related to inflammation, there was also no association between polymorphisms or haplotypes of the TNF-α gene and lung cancer risk (p>0.05). This study found no association between common variants of the TNF-α gene and lung cancer risk.