REDUCED PLASMA-FIBRINOGEN, SERUM PEROXIDES, LIPIDS, AND APOLIPOPROTEINS AFTER A 3-WEEK VEGETARIAN DIET
REDUCED PLASMA-FIBRINOGEN, SERUM PEROXIDES, LIPIDS, AND APOLIPOPROTEINS AFTER A 3-WEEK VEGETARIAN DIET
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DOI：
10.1007/bf01088096
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发表时间：
1993-01-01
影响因子：
4
通讯作者：
BERG, JE
中科院分区：
文献类型：
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作者：
HOSTMARK, AT;LYSTAD, E;BERG, JE
研究了10例中年纤维肌痛/纤维炎患者（8女2男）3周素食和禁食对血清过氧化物、脂质、载脂蛋白和血浆纤维蛋白原浓度的影响。平均血清过氧化物浓度（估计为硫代巴比妥酸反应物质）从3.60 +/- 0.14降至2.82 +/- 0.15 μ mol/l (p = 0.01)，血浆纤维蛋白原从3.33 +/- 0.25降至2.74 +/- 0.15 g/l （p = 0.02）。血清总胆固醇由6.61 +/- 0.50降至4.83 +/- 0.35 mmol/l (p < 0.0001)，载脂蛋白B由1.77 +/- 0.14降至1.31 +/- 0。载脂蛋白A从1.41 +/- 0.09降至1.23 +/- 0.05 g/l （p = 0.03）。高密度脂蛋白胆固醇浓度也有所下降（从1.26 +/- 0.09降至1.07 +/- 0.04 mmol/l, p = 0.03），反映低、高密度脂蛋白平衡的动脉粥样硬化指数下降了31%（从5.74 +/- 0.79降至3.97 +/- 0.60,p = 0.02）。结果提示，素食/禁食可能对血清过氧化物浓度和血浆纤维蛋白原浓度以及几种与脂蛋白相关的冠状动脉危险因素的血清水平有有益的影响。
The influence of a 3-week vegetarian diet and fasting on serum concentration of peroxides, lipids, apolipoproteins, and plasma fibrinogen was studied in ten middle-aged fibromyalgia/fibrositis patients (eight women, two men). Mean serum peroxide concentration (estimated as thiobarbituric acid reacting substances) was reduced from 3.60 +/- 0.14 to 2.82 +/- 0.15 umol/l (p = 0.01) and plasma fibrinogen from 3.33 +/- 0.25 to 2.74 +/- 0.15 g/l (p = 0.02). Serum total cholesterol fell from 6.61 +/- 0.50 to 4.83 +/- 0.35 mmol/l (p < 0.0001), apolipoprotein B from 1.77 +/- 0.14 to 1.31 +/- 0. 11 g/l (p < 0.0001), and apolipoprotein A from 1.41 +/- 0.09 to 1.23 +/- 0.05 g/l (p = 0.03). High density lipoprotein cholesterol concentration also decreased somewhat (from 1.26 +/- 0.09 to 1.07 +/- 0.04 mmol/l, p = 0.03) An atherogenic index, reflecting the balance between low and high density lipoproteins, was reduced by 31% (from 5.74 +/- 0.79 to 3.97 +/- 0.60, p = 0.02). The results suggest that vegetarian diet/fasting may have a beneficial influence on the concentration of serum peroxides and plasma fibrinogen concentration, and on the serum level of several lipoprotein-related coronary risk factors.