Weight loss precedes dementia in community-dwelling older adults
Weight loss precedes dementia in community-dwelling older adults
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DOI：
10.1111/j.1532-5415.1996.tb01362.x
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发表时间：
1996-10-01
影响因子：
6.3
通讯作者：
Wiederholt, WC
中科院分区：
文献类型：
--
作者：
BarrettConnor, E;Edelstein, SL;Wiederholt, WC
目的：为了确定是否与阿尔茨海默病相关的体重减轻之前或之后dementiz.DESIGN：老年社区居住的男性（n = 134）和女性（n = 165）被跟踪20年，他们被诊断为认知完整或痴呆。重复测量分析被用来比较那些谁开发阿尔茨海默氏病（AD）的体重变化与那些谁仍然cognitively intensity.MEASUREMENTS：体重是在1972-74，1984-87，和1990-93年之间的三个诊所访问测量。在1990-93年的评估中，参与者被归类为可能或可能患有AD或认知完整。诊断由两个神经科医生和神经心理测量师，神经心理测试和体检的基础上，使用NINCDS-ADRDA标准。结果：有36名男性和24名女性被诊断为可能或可能的AD，他们被认为有轻度至中度痴呆症的基础上，他们的测试成绩和社区居住状态。那些患痴呆症的人比那些被诊断为认知完整的人年龄更大。在年龄校正分析中，后来被诊断为AD的男性和女性在基线访视后体重均显著下降（分别为P <0.001和P <0.003），但在认知功能保持完整的男性和女性中，体重没有显著下降。这些差异没有解释的生活方式，抑郁症，或其他illication.CONCLUSION：体重减轻之前轻度至中度痴呆症，早期体重减轻，因此，不太可能是AD患者不能或不愿意吃的后果。
OBJECTIVE: To determine whether the weight loss associated with Alzheimer's disease precedes or follows the dementia.DESIGN: Older community-dwelling men (n = 134) and women (n = 165) were followed for 20 years before they were diagnosed as cognitively intact or demented. A repeated measures analysis was used to compare weight change in those who developed Alzheimer's Disease (AD) with those who remained cognitively intact.MEASUREMENTS: Weight was;measured at three clinic visits between 1972-74, 1984-87, and 1990-93. Participants were classified as having probable or possible AD or being cognitively intact at the 1990-93 evaluation. Diagnoses were made by two neurologists and a neuropsychometrist, based on neuropsychological tests and physical examination, using NINCDS-ADRDA criteria.RESULTS: There were 36 men and 24 women diagnosed with probable or possible AD; they were considered to have mild to moderate dementia based on their test scores and community-dwelling status. Those who developed dementia were older than those diagnosed as cognitively intact. In age-adjusted analyses, both men and women who were later diagnosed with AD had a significant decrease in weight after the baseline visit (P < .001 and P < .003, respectively), but there was no significant weight loss in the men and women who remained cognitively intact. These differences were not explained by lifestyle, depression, or other illness.CONCLUSION: Weight loss precedes mild to moderate dementia; early weight loss is, therefore, unlikely to be a consequence of AD patients being unable or unwilling to eat.