Peritoneal repair and post-surgical adhesion formation
Peritoneal repair and post-surgical adhesion formation
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DOI：
10.1093/humupd/7.6.547
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发表时间：
2001-11-01
影响因子：
13.3
通讯作者：
Campeau, JD
中科院分区：
文献类型：
--
作者：
diZeregal, GS;Campeau, JD
1919年的研究表明，腹膜愈合不同于皮肤愈合。当腹膜壁层形成缺损时，整个表面同时上皮化，而不是像皮肤伤口的表皮化那样从边缘逐渐上皮化。虽然伤口边缘的间皮细胞的增殖和迁移可能在再生过程中起着很小的作用，但它不能起主要作用，因为新的间皮细胞在大伤口的中心发育的同时也在小伤口的中心发育。腹膜内粘连的发展是一个动态过程，手术创伤组织通过纤维蛋白桥结合，纤维蛋白桥由伤口修复细胞组织起来，通常支持丰富的血管供应和神经元元素。
It was shown in 1919 that peritoneal healing differs from that of skin. When a defect is made in the parietal peritoneum the entire surface becomes epithelialized simultaneously and not gradually from the borders as in epidermalization of skin wounds. While multiplication and migration of mesothelial cells from the margin of the wound may play a small part in the regenerative process, it cannot play a major role, since new mesothelium develops in the centre of a large wound at the same time as it develops in the centre of a smaller one. Development of intraperitoneal adhesions is a dynamic process whereby surgically traumatized tissues in apposition bind through fibrin bridges which become organized by wound repair cells, often supporting a rich vascular supply as well as neuronal elements.