Inverse Relationship between Sleep Duration and Cardio-Ankle Vascular Index in Children.
Inverse Relationship between Sleep Duration and Cardio-Ankle Vascular Index in Children.
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DOI：
10.5551/jat.36517
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发表时间：
2017-08-01
影响因子：
4.4
通讯作者：
Okita K
中科院分区：
文献类型：
--
作者：
Morita N;Kambayashi I;Okuda T;Oda S;Takada S;Nakajima T;Shide N;Shinkaiya H;Okita K
目的：在成人和儿童中，睡眠质量差已被证明与心血管危险因素的发展有关，如肥胖。本研究旨在调查日本儿童和青少年的睡眠时间与动脉僵硬指数之间的关系。方法：对102名在校大学生(男56名，女46名；平均年龄11.9±1.8岁)进行调查分析。以心踝血管指数(CAVI)和心踝脉搏波速度(HaPWV)作为无创性动脉僵硬参数。通过问卷调查他们的学生的睡眠习惯(平时工作日的就寝时间和起床时间)，并在此基础上计算他们的睡眠时长。结果：CAVI值男性为4.8±0.9，女性为4.7±0.9(任意单位)。男性和女性的HPWV值分别为5.5±0.6和5.4±0.6m/S。睡眠时间与CAVI(r=−0.356)和HaPWV(r=−0.356)呈负相关，提示睡眠时间短的学生动脉僵硬可能增加。在调整了年龄、性别、收缩压、心率、肥胖和身体健康等混杂因素后，睡眠时间与CAVI的相关性仍然显著，但与HPWV无关(偏相关系数=−0.253.0 5，p<；0.0 5)。结论：我们的研究结果表明，即使在儿童时期，较短的睡眠时间也会影响动脉硬化。
Aim: Poor sleep has been shown to be associated with the development of cardiovascular risk factors, such as obesity, in both adults and children. This study aimed to investigate the relationship between sleep duration and arterial stiffness indices in Japanese children and early adolescents. Methods: The data on 102 students (56 males, 46 females; mean age, 11.9 ± 1.8 years) were analyzed. As non-invasive arterial stiffness parameters, the cardio-ankle vascular index (CAVI) and heart-ankle pulse wave velocity (haPWV) were evaluated. Their students' sleep habits (bedtime and wake times on a usual weekday) were investigated using questionnaires, and based on these, their sleep durations were calculated. Results: The CAVI values in the males and females were 4.8 ± 0.9 and 4.7 ± 0.9 (arbitrary unit), respectively. haPWV values in the males and females were 5.5 ± 0.6 and 5.4 ± 0.6 m/s, respectively. Sleep duration in the males, but not in the females, was negatively correlated with CAVI (r = −0.356) and haPWV (r = −0.356), suggesting that students with short sleep duration could have increased arterial stiffness. After adjusting for confounders, such as age, sex, systolic blood pressure, heart rate, adiposity, and physical fitness, the correlation of sleep duration with CAVI, but not with haPWV, was still significant (partial r = −0.253, p < 0.05). Conclusion: Our findings suggest that shorter sleep duration influences arterial stiffening even in childhood.