Health care-resource utilization before and after natalizumab initiation in multiple sclerosis patients in the US
Health care-resource utilization before and after natalizumab initiation in multiple sclerosis patients in the US
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DOI：
10.2147/ceor.s55779
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发表时间：
2014-01-01
影响因子：
2.1
通讯作者：
Watson, Crystal
中科院分区：
文献类型：
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作者：
Bonafede, Machaon M.;Johnson, Barbara H.;Watson, Crystal
目的：评估美国多发性硬化症(MS)相关医疗保健资源利用和成本。材料和方法：使用Truven Health MarketScan数据库进行回顾性行政索赔分析，以确定2007年1月1日至2010年12月31日期间使用Natalizumab(索引日期)的多发性硬化症(MS)确诊成人。患者连续登记24个月(指标日期前12个月和指标日期后12个月)，并在12个月后继续服用那他珠单抗。对前期接受和未接受其他疾病调整治疗(DMT)的患者进行检查。患者特征、与多发性硬化症相关的住院时间和皮质类固醇使用情况在治疗前和治疗后进行了适当的配对统计检验。结果：这项研究包括1,458名患者，平均年龄45.2岁(标准差10.5)，其中74.2%为女性。大多数人(70.3%)在孕期前使用了DMT。应用他他珠单抗后，MS相关住院患者的比例显著降低(7.6%比2.4%，P
Objectives: To evaluate multiple sclerosis (MS)-related health care-resource utilization and costs prior to and after initiating natalizumab in the US.Materials and methods: A retrospective administrative claims analysis was conducted using the Truven Health MarketScan Databases to identify adults diagnosed with MS who initiated natalizumab (index date) between January 1, 2007 and December 31, 2010. Patients had >= 24 months of continuous enrollment (12 months before [preperiod] and 12 months after [postperiod] the index date) and remained on natalizumab for the 12-month postperiod. Patients with and without other disease-modifying treatment (DMT) during the preperiod were examined. Patient characteristics, MS-related inpatient stays, and corticosteroid use were compared in the pre- and postperiods using paired statistical tests, where appropriate.Results: The study comprised 1,458 patients, mean age 45.2 years (standard deviation 10.5), 74.2% female. The majority (70.3%) used a DMT during the preperiod. After initiating natalizumab, there was a significant reduction in the percentage of patients with MS-related inpatient stays (7.6% versus 2.4%, P