The diversity of insect antiviral immunity: insights from viruses.
The diversity of insect antiviral immunity: insights from viruses.
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DOI：
10.1016/j.mib.2016.05.002
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发表时间：
2016-08
影响因子：
5.4
通讯作者：
Imler JL
中科院分区：
文献类型：
--
作者：
Marques JT;Imler JL
昆虫占所有动物物种的70%以上。最近的病毒分析揭示了昆虫病毒前所未有的遗传多样性，这似乎与它们的宿主相匹配。因此，昆虫和病毒的相互作用可能提供有关大量抗病毒免疫机制的信息。利用这种多样性是具有挑战性的，因为每种昆虫模型的独特性施加了几个限制。然而，很明显，许多保守的和不同的途径参与了昆虫病毒感染的控制。宿主和病毒之间的协同进化有利于病原体免疫逃避机制的发展。病毒抑制物可以为寄主途径提供独特的视角，强调RNA干扰、细胞凋亡以及核因子-κB途径和翻译调控在昆虫抗病毒免疫中的重要性。
Insects represent over 70% of all animal species. Recent virome analyses reveal unprecedented genetic diversity of insect viruses, which appears to match that of their hosts. Thus, insect-virus interactions may provide information on a vast repertoire of antiviral immune mechanisms. Tapping into this diversity is challenging because of several constraints imposed by the uniqueness of each insect model. Nevertheless, it is clear that many conserved and divergent pathways participate in the control of viral infection in insects. Co-evolution between hosts and viruses favors the development of immune evasion mechanisms by the pathogen. Viral suppressors can offer unique perspective on host pathways and emphasize the importance of RNA interference, apoptosis, but also NF-κB pathways and translation control in insect antiviral immunity.