Nitric oxide inhibits leucocyte migration in carrageenin-induced rat pleurisy
Nitric oxide inhibits leucocyte migration in carrageenin-induced rat pleurisy
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DOI：
10.1007/s000110050609
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发表时间：
2000-08-01
影响因子：
6.7
通讯作者：
Di Rosa, M
中科院分区：
文献类型：
--
作者：
Ialenti, A;Ianaro, A;Di Rosa, M
目的与设计：研究了一氧化氮（NO）对大鼠卡拉胶性胸膜炎白细胞迁移的影响。材料：雄性Wistar大鼠。治疗：角叉菜胶注射前1 h皮下注射l -精氨酸、NOC-18和氨基胍。方法：观察角叉菜胶刺激后4h胸膜腔白细胞积累情况。采用Bonferroni检验计算统计学显著性。结果：l -精氨酸（10 mg/kg）和NO供体NOC-18 （10 mg/kg）对白细胞浸润的抑制作用分别为31%和20% (P
Objective and Design: The role of nitric oxide (NO) on leucocyte migration has been investigated in rat carrageenin-induced pleurisy.Material: Male Wistar rats. Treatment: L-arginine, NOC-18 and aminoguanidine were administered subcutaneously 1 h prior to carrageenin injection.Methods: Leucocyte accumulation into the pleural cavity was measured 4h after carrageenin challenge. Statistical significance was calculated by Bonferroni test.Results: L-arginine (10 mg/kg) or the NO donor NOC-18 (10 mg/kg), significantly inhibited leucocyte infiltration by 31% and 20% respectively (P