What is the significance of ceroid in human atherosclerosis?
What is the significance of ceroid in human atherosclerosis?
复制标题
蜡样醇在人类动脉粥样硬化中有何意义？
DOI：
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复制
发表时间：
1987
影响因子：
4.6
通讯作者：
M. Mitchinson
中科院分区：
文献类型：
--
作者：
R. Ball;K. H. Carpenter;M. Mitchinson
对动脉粥样硬化内膜中蜡样质重要性的回顾表明，巨噬细胞在其产生中发挥着核心作用。 Ceroid 不仅仅是一种“年龄色素”。它标志着先前氧化事件的发生地点，可能包括生物活性或有毒、可溶性氧化分子的释放。因此，巨噬细胞的这种活性可能在病变的进展中发挥重要作用。因此，巨噬细胞和可氧化不饱和脂质的相互作用值得进一步研究。
This review of the significance of ceroid within the atherosclerotic intima proposes that the macrophages have a central role to play in its production. Ceroid is more than merely an "age pigment." It marks the site of previous oxidative events, possibly including the release of biologically active or toxic, soluble oxidized molecules. This being so, this activity of macrophages may have a significant role in the progression of the lesions. The interactions of macrophages and oxidizable unsaturated lipids therefore merit further investigation.