Genetic analysis of two influenza A (H1) swine viruses isolated from humans in Thailand and the Philippines
Genetic analysis of two influenza A (H1) swine viruses isolated from humans in Thailand and the Philippines
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DOI：
10.1007/s11262-007-0097-9
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发表时间：
2007-10-01
期刊：
影响因子：
1.6
通讯作者：
Barr, I. G.
中科院分区：
文献类型：
--
作者：
Komadina, N.;Roque, V.;Barr, I. G.
从两名男性身上分离出流感病毒A/菲律宾/341/2004 （H1N2）和A/泰国/271/2005 (H1N1)，轻度流感提供了当代猪流感散发人间感染的证据。这两种病毒在抗原性和遗传上都不同于在人群中传播的甲型H1N1和H1N2流感病毒。对血凝素基因的遗传分析发现，这些病毒与在亚洲和北美流行的经典猪H1病毒具有最高程度的相似性。神经氨酸酶基因和内部基因被发现与在欧洲猪中传播的病毒更密切相关，这些病毒似乎经历了多次重组事件。虽然猪流感传播给人类似乎是一个相对罕见的事件，但猪被认为是产生潜在大流行性流感病毒的中间宿主，这种病毒可能有能力引起人类流行，导致高发病率和死亡率。
Influenza viruses A/Philippines/341/2004 (H1N2) and A/Thailand/271/2005 (H1N1) were isolated from two males, with mild influenza providing evidence of sporadic human infection by contemporary swine influenza. Both viruses were antigenically and genetically distinct from influenza A (H1N1 and H1N2) viruses that have circulated in the human population. Genetic analysis of the haemagglutinin genes found these viruses to have the highest degree of similarity to the classical swine H1 viruses circulating in Asia and North America. The neuraminidase gene and the internal genes were found to be more closely related to viruses circulating in European swine, which appear to have undergone multiple reassorting events. Although transmission of swine influenza to humans appears to be a relatively rare event, swine have been proposed as the intermediate host in the generation of potential pandemic influenza virus that may have the capacity to cause human epidemics resulting in high morbidity and mortality.