MSX1-A Potential Marker for Uterus-Preserving Therapy of Endometrial Carcinomas
MSX1-A Potential Marker for Uterus-Preserving Therapy of Endometrial Carcinomas
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DOI：
10.3390/ijms21124529
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发表时间：
2020-06-01
影响因子：
5.6
通讯作者：
Heidegger, Helene Hildegard
中科院分区：
文献类型：
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作者：
Eppich, Simon;Kuhn, Christina;Heidegger, Helene Hildegard
预后因素是子宫内膜癌患者非常感兴趣的。一个潜在的因素可能是MSX1蛋白，一种转录抑制因子，对细胞周期有抑制作用。在本研究中，对子宫内膜样子宫内膜癌（53例）、透明细胞子宫内膜癌（6例）、子宫内膜样卵巢癌（19例）和透明细胞卵巢癌（11例）进行MSX1蛋白免疫化学染色，并使用免疫反应评分（IRS）进行评估。MSX1在子宫内膜样子宫内膜癌（p< 0.001）、2级（中度分化）子宫内膜癌（p= 0.001）和未受损伤淋巴结患者的肿瘤材料中表达明显增强（p= 0.031）。MSX1的表达与β - catenin、p21、p53以及类固醇受体ER α、ER β、PR α和PR β的表达存在相关性。在子宫内膜样子宫内膜癌中，MSX1在超过10%的肿瘤细胞中表达的患者的生存率显著提高（p= 0.023）（中位生存期21.3年（MSX1阳性）对17.3年（MSX1阴性））。虽然有证据表明MSX1表达与改善的长期生存相关，但需要进一步的研究来评估MSX1是否可以作为预后标志物。
Prognostic factors are of great interest in patients with endometrial cancer. One potential factor could be the protein MSX1, a transcription repressor, that has an inhibitory effect on the cell cycle. For this study, endometrioid endometrial carcinomas (n= 53), clear cell endometrial carcinomas (n= 6), endometrioid ovarian carcinomas (n= 19), and clear cell ovarian carcinomas (n= 11) were immunochemically stained for the protein MSX1 and evaluated using the immunoreactive score (IRS). A significant stronger expression of MSX1 was found in endometrioid endometrial carcinomas (p< 0.001), in grading 2 (moderate differentiation) (p= 0.001), and in tumor material of patients with no involvement of lymph nodes (p= 0.031). Correlations were found between MSX1 expression and the expression of beta-Catenin, p21, p53, and the steroid receptors ER alpha, ER beta, PR alpha, and PR beta. A significant (p= 0.023) better survival for patients with an MSX1 expression in more than 10% of the tumor cells was observed for endometrioid endometrial carcinomas (21.3 years median survival (MSX1-positive) versus 17.3 years (MSX1-negative)). Although there is evidence that MSX1 expression correlates with improved long-term survival, further studies are necessary to evaluate if MSX1 can be used as a prognostic marker.