Aspirin‐like effects of selected food additives and industrial sensitizing agents
Aspirin‐like effects of selected food additives and industrial sensitizing agents
复制标题
选定食品添加剂和工业敏化剂的阿司匹林样作用
DOI：
10.1111/j.1365-2222.1989.tb02429.x
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发表时间：
1989
影响因子：
6.1
通讯作者：
B. H. Davies
中科院分区：
文献类型：
--
作者：
W. Williams;A. Pawlowicz;B. H. Davies
在测量去甲肾上腺素激活血小板的测试中，研究了一些食品添加剂和工业化学品，它们是导致一些人出现不耐受症状的原因。所有被研究的药物都抑制了血小板聚集，这与抑制环氧合酶-血栓素途径有关。当它们成对测试时，或者与水杨酸盐或阿司匹林一起测试时，所研究的药物的次优抑制浓度对血小板聚集具有相加的抑制作用。结果支持这样一种理论，即一些食品添加剂和工业化学品由于其类似阿司匹林的特性而导致不耐受。
A number of food additives and industrial chemicals, responsible for inducing symptoms of intolerance in some individuals, have been studied in tests measuring platelet activation by noradrenaline. All the investigated agents inhibited platelet aggregation and this was associated with inhibition of the cyclo‐oxygenase‐thromboxane pathway. Suboptimal inhibitory concentrations of the agents studied had additive inhibitory effects on platelet aggregation when they were tested in pairs, or when tested with salicylate or aspirin. The results support the theory that some food additives and industrial chemicals induce intolerance because of their aspirin‐like properties.