Experimental validation of the hyperpolarized 129Xe chemical shift saturation recovery technique in healthy volunteers and subjects with interstitial lung disease
Experimental validation of the hyperpolarized 129Xe chemical shift saturation recovery technique in healthy volunteers and subjects with interstitial lung disease
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DOI：
10.1002/mrm.25400
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发表时间：
2015-07-01
影响因子：
3.3
通讯作者：
Wild, Jim M.
中科院分区：
文献类型：
--
作者：
Stewart, Neil J.;Leung, General;Wild, Jim M.
目的评价超极化129化学位移饱和恢复（CSSR）技术对特发性肺纤维化（IPF）和系统性硬化症（SSc）患者肺微结构和功能变化的无创性定量的敏感性。使用二项式复合射频脉冲实现CSSR脉冲序列，以监测组织和血浆（T/P）和红细胞（RBC）中的γ-129磁化。用三种现有的气体扩散分析模型拟合了这些隔室中的NH 4 -129摄取的动力学，以提取肺生理学参数。这些参数之间进行了定量比较models. ResultsTakeup氙气进入肺毛细血管受损的IPF和SSc的受试者。在IPF患者中，通过EEG-129 CSSR测量到具有统计学意义的间隔增厚。初步数据表明，健康志愿者的间隔厚度随年龄变化。使用每种文献模型重现这些结果。CSSR衍生的参数进行了比较与肺功能的金标准指标;一氧化碳弥散量和肺的transit-time.ConclusionsCSSR与超极化的RESINS-129是敏感的病理引起的肺结构/功能的退化，并显示量化的疾病严重程度和监测治疗反应的承诺。Magn Reson Med 74：196-207，2015。(c)2014 Wiley Periodicals，Inc.
PurposeTo assess the sensitivity of the hyperpolarized Xe-129 chemical shift saturation recovery (CSSR) technique for noninvasive quantification of changes to lung microstructure and function in idiopathic pulmonary fibrosis (IPF) and systemic sclerosis (SSc).MethodsTen healthy volunteers, four subjects with SSc and four with IPF were scanned at 1.5 T. A CSSR pulse sequence was implemented using binomial-composite radiofrequency pulses to monitor Xe-129 magnetization in tissues and blood plasma (T/P) and red blood cells (RBCs). The dynamics of Xe-129 uptake into these compartments were fitted with three existing analytical models of gas diffusion to extract parameters of lung physiology. These parameters were quantitatively compared between models.ResultsUptake of xenon into the pulmonary capillaries was impaired in subjects with IPF and SSc. Statistically significant septal thickening was measured by Xe-129 CSSR in IPF patients. Preliminary data suggests age-dependent alterations to septal thickness in healthy volunteers. These findings were reproduced using each of the literature models. CSSR-derived parameters were compared with gold-standard indicators of pulmonary function; diffusing capacity of carbon monoxide and pulmonary transit-time.ConclusionsCSSR with hyperpolarized Xe-129 is sensitive to pathology-induced degradation of lung structure/function and shows promise for quantification of disease severity and monitoring treatment response. Magn Reson Med 74:196-207, 2015. (c) 2014 Wiley Periodicals, Inc.