BEHAVIORAL-EFFECTS OF ROLIPRAM AND STRUCTURALLY RELATED-COMPOUNDS IN MICE - BEHAVIORAL SEDATION OF CAMP PHOSPHODIESTERASE INHIBITORS
BEHAVIORAL-EFFECTS OF ROLIPRAM AND STRUCTURALLY RELATED-COMPOUNDS IN MICE - BEHAVIORAL SEDATION OF CAMP PHOSPHODIESTERASE INHIBITORS
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DOI：
10.1016/0091-3057(91)90186-6
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发表时间：
1991-06-01
影响因子：
3.6
通讯作者：
BOURGUIGNON, JJ
中科院分区：
文献类型：
--
作者：
GRIEBEL, G;MISSLIN, R;BOURGUIGNON, JJ
研究了特异性cAMP磷酸二酯酶抑制剂（PDE-I）如咯利普兰和结构相关化合物对小鼠行为的影响。 选择的PDE-I诱导了一个强大的剂量依赖性减少运动和饲养面临着一个自由的探索性程序的小鼠，这些影响被认为是一种行为镇静。 然而，在光/暗选择试验，特别是设想揭示去抑制和/或抗焦虑作用，他们没有表现出明显的效果。 这些结果表明，cAMP的增加可能不能解释我们先前观察到的BW A78U（一种腺嘌呤衍生物PDE-I）的抗焦虑特性（20）。
The behavioral effects of specific cAMP phosphodiesterase inhibitors (PDE-I) such as rolipram and structurally related compounds were investigated in mice. Selected PDE-I induced a potent dose-dependent decrease in locomotion and in rearing of mice confronted with a free exploratory procedure, these effects being considered as a behavioral sedation. However, in the light/dark choice test especially conceived to reveal disinhibitory and/or anxiolytic action, they did not show obvious effects. These results suggest that the increase of cAMP probably does not account for our previously observed anxiolytic properties of BW A78U, an adenine derivative PDE-I (20).