Pretransplant immune-regulation predicts allograft tolerance.
Pretransplant immune-regulation predicts allograft tolerance.
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DOI：
10.1111/j.1600-6143.2011.03484.x
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发表时间：
2011-06
期刊：
影响因子：
--
通讯作者：
Burlingham WJ
中科院分区：
文献类型：
--
作者：
Dutta P;Dart M;Roenneburg DA;Torrealba JR;Burlingham WJ
CD4+ Tregs specific for non-inherited maternal antigens (NIMAd) are detectable in some but not all B6 × BDF1 backcross, H-2b homozygous offspring, and their presence is strongly correlated with extent of maternal (BDF1) microchimerism. We hypothesized that the level of pre-transplant donor antigen-specific Tregs could predict allograft tolerance. To test this idea, mice were screened for bystander suppression in a DTH assay, followed 1 wk later by DBA/2 heterotopic heart transplantation. NIMAd-exposed, H-2b offspring that failed to suppress DTH uniformly rejected heart allografts (12/12) by d15. In contrast, 5/6 NIMAd-exposed DTH “regulators” accepted their allografts >100d. The defect in ‘non-regulator’ offspring could be corrected by transfer of CD4+CD25+, but not CD4+CD25neg or CD8+T cells from transplant acceptor mice. Donor-specific T reg screening of F1 backcross offspring correctly predicted which recipients would accept a heart allograft. If translated to the clinic, similar pre-transplant Treg screening could greatly enhance the effectiveness of tolerance as a clinical strategy in transplantation between family members.
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影响因子：
4.4
作者：
Andrassy, J;Kusaka, S;Burlingham, WJ
通讯作者：
Burlingham, WJ
影响因子：
4.4
作者：
Molitor-Dart, Melanie L.;Andrassy, Joachim;Burlingham, William J.
通讯作者：
Burlingham, William J.
DOI：
10.4161/chim.1.2.14295
发表时间：
2010-10
期刊：
Chimerism
影响因子：
--
作者：
Dutta P;Dart ML;Schumacher SM;Burlingham WJ
通讯作者：
Burlingham WJ
影响因子：
20.3
作者：
Dutta, Partha;Molitor-Dart, Melanie;Burlingham, William J.
通讯作者：
Burlingham, William J.
影响因子：
6.2
作者：
Poggio, Emilio D.;Augustine, Joshua J.;Heeger, Peter S.
通讯作者：
Heeger, Peter S.