Sclerosing hemangioma with lymph node metastasis
Sclerosing hemangioma with lymph node metastasis
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DOI：
10.3349/ymj.2003.44.1.150
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发表时间：
2003-02-01
影响因子：
2.4
通讯作者：
Kang, DY
中科院分区：
文献类型：
--
作者：
Kim, KH;Sul, HJ;Kang, DY
肺硬化性血管瘤是一种少见的肿瘤，由多角形和立方形细胞组成。这种疾病通常被认为是良性的，但极罕见的情况下，淋巴结转移的报告。我们报告一个病例SH转移到区域淋巴结。一个19岁的女孩，有2年的咳嗽史。胸部X光和CT扫描显示下肺叶有一个大肿块。因此，进行了左下叶切除术，并清除了肺门和叶间淋巴结。肿瘤是一个边界清楚的巨大肿块，部分粘连到纵隔和壁层胸膜。肺门、叶间和肺内淋巴结的解剖显示转移。组织学上，原发瘤和转移瘤由多边形和立方形细胞组成。这两种类型的肿瘤细胞均免疫反应上皮膜抗原（EMA）和甲状腺转录因子-1（TTF-1）。然而，立方细胞测试呈阳性的泛细胞角蛋白，而多边形细胞测试始终阴性。术后，患者接受化疗，术后2年未见复发或转移。虽然肺SH被认为是良性的，这种情况下强调需要评估淋巴结转移。
Sclerosing hemangioma (SH) of the lung is an uncommon type of tumor, which is composed of polygonal and cuboidal cells. This disease is generally regarded as benign but extremely rare cases with lymph node metastasis have been reported. We report a case of SH with a metastasis to the regional lymph nodes. A 19-year-old girl presented with a 2-year history of coughing. A chest X-ray and a CT scan indicated a large mass in the lower lobe. As a result, a left lower lobectomy with a dissection of the hilar and interlobar lymph nodes was performed. The tumor was a well-defined huge mass with partial adhesion to the mediastinal and parietal pleura. The dissected hilar, interlobar, and intrapulmonary lymph nodes demonstrated metastasis. Histologically, the primary and metastatic tumor consisted of polygonal and cuboidal cells. Both types of tumor cells were uniformly immunoreactive to the epithelial membrane antigen (EMA) and the thyroid transcription factor-1 (TTF-1). However, the cuboidal cells tested positive for pancytokeratin, whereas the polygonal cells tested consistently negative. Postoperatively, the patient received chemotherapy and no recurrence or metastasis 2 years after surgery was noted. Although a pulmonary SH is considered to be benign, this case highlights the need for the evaluation of lymph node metastasis.