Multistage regulation of Th1-type immune responses by the transcription factor IRF-1
Multistage regulation of Th1-type immune responses by the transcription factor IRF-1
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DOI：
10.1016/s1074-7613(00)80443-4
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发表时间：
1997-06-01
期刊：
影响因子：
32.4
通讯作者：
Asano, Y
中科院分区：
文献类型：
--
作者：
Taki, S;Sato, T;Asano, Y
特定病原体的根除依赖于辅助性T（Th）细胞向Th 1或Th 2类型的选择性分化。我们在这里表明，缺乏转录因子IRF-1的小鼠的T细胞未能安装Th 1应答，而是专门在体外进行Th 2分化。Th 1分化受损与多种细胞类型的缺陷有关，即巨噬细胞产生白细胞介素-12受损、CD 4（+）T细胞对白细胞介素-12的低反应性以及自然杀伤细胞发育缺陷。这些结果表明IRF-1参与免疫应答的Th 1分支的多个阶段。
Eradication of a given pathogen is dependent on the selective differentiation of T helper (Th) cells into Th1 or Th2 types. We show here that T cells from mice lacking the transcription factor IRF-1 fail to mount Th1 responses and instead exclusively undergo Th2 differentiation in vitro. Compromised Th1 differentiation is found to be associated with defects in multiple cell types, namely impaired production of interleukin-12 by macrophages, hyporesponsiveness of CD4(+) T cells to interleukin-12, and defective development of natural killer cells. These results indicate the involvement of IRF-1 in multiple stages of the Th1 limb of the immune response.