Evaluation of cyclooxygenase-1 and cyclooxygenase-2 expression and the effect of cyclooxygenase inhibitors in canine prostatic carcinoma.
Evaluation of cyclooxygenase-1 and cyclooxygenase-2 expression and the effect of cyclooxygenase inhibitors in canine prostatic carcinoma.
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DOI：
10.1111/j.1476-5810.2004.00035.x
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发表时间：
2004-03-01
影响因子：
2.1
通讯作者：
Ferracone, J
中科院分区：
文献类型：
--
作者：
Sorenmo, K U;Goldschmidt, M H;Ferracone, J
前列腺癌主要发生在老年被阉割的公狗身上，通常是一种致命的疾病（大多数狗在最初诊断后几个月内死亡）。手术，即全前列腺切除术，或放射治疗往往不追求由于并发症的风险和远端转移率高。环氧化酶-2 （Cox-2）在包括犬前列腺癌在内的多种恶性肿瘤中均有表达。据报道，Cox-2抑制对几种人类恶性肿瘤具有预防作用，并对实验室和自发肿瘤模型具有治疗作用。本回顾性研究的目的是评估Cox表达和Cox抑制剂对前列腺癌犬存活的影响。94.1%的肿瘤表达Cox-1, 88.2%的肿瘤表达Cox-2。此外，接受Cox抑制剂（吡罗西康或卡洛芬）治疗的狗的寿命明显长于未接受治疗的狗，分别为6.9个月和0.7个月（P < 0.0001），这表明Cox抑制剂可能在犬前列腺癌治疗中发挥重要作用。
Prostatic carcinoma occurs primarily in older castrated male dogs and is typically a fatal disease (most dogs die within few months after the initial diagnosis). Surgery, i.e., total prostatectomy, or radiation therapy is often not pursued due to risks of complications and a high rate of distant metastasis. Cyclooxygenase-2 (Cox-2) expression has been documented in several malignancies, including canine prostatic carcinoma. Cox-2 inhibition has been reported to have preventative effects on several human malignancies and has therapeutic effects on both laboratory and spontaneous tumour models. The purpose of this retrospective study was to evaluate Cox expression and the effects of Cox inhibitors on survival in dogs with prostatic carcinoma. 94.1 and 88.2% of the tumours expressed Cox-1 and Cox-2, respectively. Furthermore, dogs treated with Cox inhibitors (piroxicam or carprofen) lived significantly longer than untreated dogs, 6.9 versus 0.7 months (P < 0.0001), suggesting that Cox inhibitors may have an important role in canine prostate cancer therapy.