Extracellular release of antigenic proteins by Helicobacter pylori
Extracellular release of antigenic proteins by Helicobacter pylori
复制标题
DOI：
10.1128/iai.66.6.2984-2986.1998
复制
发表时间：
1998-06-01
影响因子：
3.1
通讯作者：
Cover, TL
中科院分区：
文献类型：
--
作者：
Cao, P;McClain, MS;Cover, TL
利用幽门螺杆菌肉汤培养上清抗血清筛选幽门螺杆菌基因组文库，鉴定出6种抗原：脲酶、HspB、Lpp20、DnaK、MsrA和富含半胱氨酸的28-kDa蛋白（称为HcpA）。幽门螺杆菌抗原可能通过多种机制释放到细胞外空间，包括特定的分泌途径、自溶和膜泡形成。
Screening a Helicobacter pylori genomic library with antisera raised against H. pylori broth culture supernatant resulted in the identification of six antigens: urease, HspB, Lpp20, DnaK, MsrA, and a cysteine-rich 28-kDa protein (designated HcpA). H. pylori antigens may be released into the extracellular space by multiple mechanisms, including specific secretion pathways, autolysis, and membrane vesicle formation.