Lesion of hypothalamic paraventricular nucleus and maternal aggressive behavior in female rats
Lesion of hypothalamic paraventricular nucleus and maternal aggressive behavior in female rats
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DOI：
10.1016/0031-9384(95)02117-5
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发表时间：
1996-04-01
影响因子：
2.9
通讯作者：
Lucion, AB
中科院分区：
文献类型：
--
作者：
Consiglio, AR;Lucion, AB
产后第 3 至 12 天的哺乳期雌性大鼠比非哺乳期雌性大鼠对入侵者雄性更具攻击性。在这项研究中，通过在产后第五天、第七天和第九天将陌生的雄性引入雌性及其后代的领地，记录了产妇的攻击行为。产后第五天进行下丘脑室旁核（PVN）的电解损伤。结果表明，PVN 病变减少了入侵者攻击的频率和持续时间。此外，与假损伤组的幼崽相比，损伤导致幼崽的体重增加减少。结果表明，PVN 参与了大鼠母体攻击性的调节。讨论了催产素在该行为中的可能作用。
Lactating female rats on the 3rd to 12th day postpartum are more aggressive towards an intruder male than are nonlactating females. In this study, maternal aggressive behavior was recorded by introducing a strange male in the territory of the female and her offspring, on the fifth, seventh, and ninth day postpartum. Electrolytic lesions of the paraventricular nucleus of the hypothalamus (PVN) were performed on the fifth day postpartum. The results showed that the PVN lesion reduced the frequency and duration of attacks on the intruder. In addition, the lesion caused reduced weight gain in the pups compared to pups of the sham lesion group. The results suggest that PVN participates in the modulation of maternal aggression in rats. A possible role of oxytocin in that behavior is discussed.