Discriminating between allelic and interlocus differences among human immunoglobulin V(H)4 sequences by analyzing single spermatozoa
Discriminating between allelic and interlocus differences among human immunoglobulin V(H)4 sequences by analyzing single spermatozoa
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DOI：
10.1007/s004390050472
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发表时间：
1997-07-01
期刊：
影响因子：
5.3
通讯作者：
Li, HH
中科院分区：
文献类型：
--
作者：
Cui, XF;Li, HH
To address the challenging issue of distinguishing allelic and interlocus differences among repetitive sequences, human immunoglobulin V(H)4 loci in the parental haplotypes of 13 donors were determined by analyzing single spermatozoa. V(H)4 sequences detected among these donors were assigned to their corresponding loci based on the fact that allelic sequences usually segregate into different gametes. Four our of the ten V(H)4 loci were shown to contain null alleles that are undetectable with diploid materials, The distribution of the allelic variation within the analyzed regions at the V(H)4 loci is highly biased.
