Stability of body weight in type 2 diabetes
Stability of body weight in type 2 diabetes
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DOI：
10.2337/diacare.29.03.06.dc05-1703
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发表时间：
2006-03-01
期刊：
影响因子：
16.2
通讯作者：
Nuttall, FQ
中科院分区：
文献类型：
--
作者：
Chaudhry, ZW;Gannon, MC;Nuttall, FQ
目标——人们担心社会上正在出现“肥胖流行病”。肥胖的后果之一是可能患上 2 型糖尿病。据推测，糖尿病患者的体重会继续大幅增加，并且可能会因药物治疗而加速。在这项回顾性研究中，我们测试了糖尿病人群的增益大于普通人群的假设。 研究设计和方法 - 数据来自就诊糖尿病诊所 5 年的成年男性的记录。将他们的体重和上次访问时的体重与初始访问数据进行比较。将受试者分类为治疗方式。平均随访时间为 9.4 年（范围 5-23）。 结果 - 对于整个组来说，体重平均增加为 0.23 +/- 0.2 kg/年，BMI 或初始年龄对体重增加率影响不大。使用的治疗方案对体重变化有影响。在接受或不接受胰岛素治疗的受试者中，体重以每年 0.44 +/- 0.1 公斤的速度增加。在接受二甲双胍和磺酰脲类药物治疗的受试者中，体重平均下降，即 -0.24 +/- 0.09 kg/年，单独使用磺酰脲类药物时体重增加了 0.42 +/- 0.2 kg/年。 结论 - 单独使用胰岛素或胰岛素联合口服胰岛素治疗的男性体重增加速度与一般人群报告的相当，即体重增加并不特别。二甲双胍治疗导致体重适度减轻。
OBJECTIVE - There is a concern that an "epidemic of obesity" is occurring in societies. One consequence of obesity is that type 2 diabetes may develop. Presumably, a great increase in body weight would continue in people With diabetes and may be accelerated due pharmacological treatment. In this retrospective study, we tested the hypothesis that the gain in a diabetic population is greater than that in the general population.RESEARCH DESIGN AND METHODS - Data were obtained from the records of adult men who have attended a diabetes clinic for :5 years. Their weight and at the last visit were compared with the initial Visit data. The subjects were Categorized to treatment modalities. The mean follow-up was 9.4 years (range 5-23).RESULTS - For the group as a whole, the mean increase in body weight was 0.23 +/- 0.2 kg/year, BMI or initial age had little effect on the rate of weight gain. Treatment regimen used have an effect on weight change. In subjects treated with insulin, with or without oral body weight increased at a rate of 0.44 +/- 0.1 kg/year. In subjects treated With metformin metformin and a sulfonylurea, there was a mean loss in weight, i.e., -0.24 +/- 0.09 kg/year, with sulfonylureas alone weight increased by 0.42 +/- 0.2 kg/year.CONCLUSIONS - The men treated With insulin alone or insulin combined With oral gained weight at a rate comparable with that reported for the general population, i.e., the gain was not extraordinary. Metformin treatment resulted in a modest loss of weight.