Dimercaptosuccinic acid in the treatment of depression following lead exposure.
Dimercaptosuccinic acid in the treatment of depression following lead exposure.
复制标题
二巯基丁二酸治疗铅暴露后的抑郁症。
DOI：
10.1002/ajim.4700240606
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发表时间：
1993
影响因子：
3.5
通讯作者：
Gerr,F
中科院分区：
文献类型：
--
作者：
Frumkin,H;Gerr,F
已知长期接触铅会引起各种神经毒性表现，包括抑郁症症状。二巯基琥珀酸（DMSA）是一种最近被批准的口服螯合剂，可以减轻铅的身体负担，但很少有治疗后临床改善的病例报告。我们报告了一个中重度抑郁症的病例，在一个长期的领导工人，似乎对DMSA有显著的反应。这一反应表明DMSA在治疗铅暴露患者的抑郁症中可能具有治疗作用。©1993 Wiley‐Liss, Inc。
Long‐term exposure to lead is known to cause a variety of neurotoxic manifestations, including symptoms of depression. Dimercaptosuccinic acid (DMSA), a recently approved oral chelating agent, can diminish the body burden of lead, but few cases of documented clinical improvement following treatment have been reported. We report a case of moderate to severe depression in a long‐term lead worker that appeared to respond dramatically to DMSA. This response suggests a possible therapeutic role for DMSA in the treatment of depression in lead‐exposed patients. © 1993 Wiley‐Liss, Inc.