MicroRNAs associated with exercise and diet: a systematic review
MicroRNAs associated with exercise and diet: a systematic review
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DOI：
10.1152/physiolgenomics.00095.2014
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发表时间：
2015-01-01
影响因子：
4.6
通讯作者：
Fukuoka, Yoshimi
中科院分区：
文献类型：
--
作者：
Flowers, Elena;Won, Gloria Y.;Fukuoka, Yoshimi
MicroRNA 反映了个体对环境暴露的生物适应。因此，循环 microRNA 的测量为评估与减肥行为干预（即运动、饮食）相关的生物学变化提供了机会。本研究的目的是对文献进行系统回顾，总结与运动、饮食和减肥相关的循环 microRNA 的已知信息。我们对三个科学数据库进行了系统审查。我们纳入了与人类运动、饮食和减肥相关的循环 microRNA 的研究报告。在我们的综合数据库搜索中确定了 1,219 项研究，其中 14 项被选中纳入。 12 份报告了与运动相关的 microRNA，2 份报告了与饮食和减肥相关的 microRNA。大多数研究采用准实验横断面设计。运动和饮食干预的类型和强度、microRNA 的生物来源以及定量 microRNA 的方法学方法存在许多差异。多项研究的数据支持循环 microRNA 与运动之间的关联。由于研究数量较少，循环 microRNA 与饮食之间关联的证据较弱。需要进行更多研究来验证之前的观察结果，使用方法学上严格的 microRNA 定量方法来确定与减肥行为方法相关的特定循环 microRNA 特征。未来的方向包括纵向研究，以确定循环的 microRNA 是否可以预测对行为干预的反应。
MicroRNAs reflect individual biologic adaptation to exposures in the environment. As such, measurement of circulating microRNAs presents an opportunity to evaluate biologic changes associated with behavioral interventions (i.e., exercise, diet) for weight loss. The aim of this study was to perform a systematic review of the literature to summarize what is known about circulating microRNAs associated with exercise, diet, and weight loss. We performed a systematic review of three scientific databases. We included studies reporting on circulating microRNAs associated with exercise, diet, and weight loss in humans. Of 1,219 studies identified in our comprehensive database search, 14 were selected for inclusion. Twelve reported on microRNAs associated with exercise, and two reported on microRNAs associated with diet and weight loss. The majority of studies used a quasiexperimental, cross-sectional design. There were numerous differences in the type and intensity of exercise and dietary interventions, the biologic source of microRNAs, and the methodological approaches used quantitate microRNAs. Data from several studies support an association between circulating microRNAs and exercise. The evidence for an association between circulating microRNAs and diet is weaker because of a small number of studies. Additional research is needed to validate previous observations using methodologically rigorous approaches to microRNA quantitation to determine the specific circulating microRNA signatures associated with behavioral approaches to weight loss. Future directions include longitudinal studies to determine if circulating microRNAs are predictive of response to behavioral interventions.