Comparison of disease activity measures for anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis.
Comparison of disease activity measures for anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis.
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DOI：
10.1136/ard.2008.097758
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发表时间：
2009-01
影响因子：
27.4
通讯作者：
Vasculitis Clinical Research Consortium
中科院分区：
文献类型：
--
作者：
Merkel PA;Cuthbertson DD;Hellmich B;Hoffman GS;Jayne DR;Kallenberg CG;Krischer JP;Luqmani R;Mahr AD;Matteson EL;Specks U;Stone JH;Vasculitis Clinical Research Consortium
目前，在抗中性粒细胞胞浆抗体（ANCA）相关性血管炎的临床试验中，使用了几种不同的仪器来测量疾病活动和程度，导致研究组之间的分裂和难以比较研究结果。进行了一项比较六种不同血管炎器械的练习。来自5个国家的10名经验丰富的血管炎研究者使用6种疾病评估工具对韦格纳肉芽肿或显微镜下多血管炎文献中的20例病例进行了评分：伯明翰血管炎活动性评分（BVAS）、韦格纳肉芽肿BVAS（BVAS/WG）、BVAS 2003、医生总体评估（PGA）、疾病程度指数（DEI）和五因素评分（FFS）。5例病例由所有评定者重新评分。这些措施的可靠性非常高（六项措施的组内相关系数均为0.98）。在每种工具中，10名研究者的评分之间没有显著差异或离群值。测试/重测信度是高的每一个措施：范围=0.77至0.95。五项急性活动指标的得分彼此之间的相关性非常好。目前可用的测量ANCA相关性血管炎的疾病程度和活动性的工具是高度相关和可靠的。这些结果为研究人员提供了信心，以比较不同的临床试验数据，并有助于形成共同点，因为国际研究小组开发新的，改进的和普遍接受的血管炎疾病评估工具。
Currently, several different instruments are used to measure disease activity and extent in clinical trials of anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis, leading to division among investigative groups and difficulty comparing study results. An exercise comparing six different vasculitis instruments was performed. A total of 10 experienced vasculitis investigators from 5 countries scored 20 cases in the literature of Wegener granulomatosis or microscopic polyangiitis using 6 disease assessment tools: the Birmingham Vasculitis Activity Score (BVAS), The BVAS for Wegener granulomatosis (BVAS/WG), BVAS 2003, a Physician Global Assessment (PGA), the Disease Extent Index (DEI) and the Five Factor Score (FFS). Five cases were rescored by all raters. Reliability of the measures was extremely high (intraclass correlations for the six measures all=0.98). Within each instrument, there were no significant differences or outliers among the scores from the 10 investigators. Test/retest reliability was high for each measure: range=0.77 to 0.95. The scores of the five acute activity measures correlated extremely well with one another. Currently available tools for measuring disease extent and activity in ANCA-associated vasculitis are highly correlated and reliable. These results provide investigators with confidence to compare different clinical trial data and helps form common ground as international research groups develop new, improved and universally accepted vasculitis disease assessment instruments.
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影响因子：
158.5
作者：
Jayne, D;Rasmussen, N;Pusey, C
通讯作者：
Pusey, C
DOI：
10.1002/art.10922
发表时间：
2003-02-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Guillevin, L;Cohen, P;Cordier, JF
通讯作者：
Cordier, JF
影响因子：
1.6
作者：
Guillevin, L;Lhote, F;Casassus, P
通讯作者：
Casassus, P
影响因子：
--
作者：
Seo, P;Min, YI;Stone, JH
通讯作者：
Stone, JH
影响因子：
--
作者：
Guillevin, L;Cordier, JF;Longy-Boursier, M
通讯作者：
Longy-Boursier, M