PIGMENTARY AND CUTANEOUS RISK-FACTORS FOR NON-MELANOCYTIC SKIN-CANCER - A CASE-CONTROL STUDY
PIGMENTARY AND CUTANEOUS RISK-FACTORS FOR NON-MELANOCYTIC SKIN-CANCER - A CASE-CONTROL STUDY
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DOI：
10.1002/ijc.2910480504
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发表时间：
1991-07-09
影响因子：
6.4
通讯作者：
HEENAN, PJ
中科院分区：
文献类型：
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作者：
KRICKER, A;ARMSTRONG, BK;HEENAN, PJ
在一项组织病理学证实的皮肤癌流行病例和事件病例的病例对照研究中，研究了种族来源、色素特征、阳光敏感性和其他皮肤特征作为基底细胞癌（BCC）和鳞状细胞癌（SCC）危险因素的作用。1987年在西澳大利亚的杰拉尔顿进行了一项基于人群的皮肤癌调查，发现了226例确诊的BCC， 45例SCC和1015例无病变的对照。本土出生的澳大利亚人患这两种癌症的风险都高于移民。BCC的风险随着到达澳大利亚时年龄的增加而降低。南欧血统对BCC（任何南欧祖父母）和SCC（没有SCC病例的祖父母有南欧血统）有很强的保护作用。不能晒黑是BCC和SCC最强的色素危险因素。在包括阳光照射和阳光敏感性的因素中，儿童时期手臂上的雀斑对两种癌症都很重要，背上的痣数量对BCC很重要，前臂皮肤颜色以及颈部和邻近保护区域之间的永久性颜色差异对SCC很重要。在太阳对皮肤的损伤测量中，颈部的太阳弹性是BCC和SCC的一个强大的危险因素，手背皮肤精细纹理的丧失（通过皮肤微地形测量）对于BCC和SCC的面部毛细血管扩张是重要的。当每种癌症的所有重要变量与年龄、性别、移民身份或抵达澳大利亚的年龄和种族一起在单一模型中进行检查时，无法晒黑、颈部太阳弹性症和背部痣数量是BCC和颈部太阳弹性症的独立显著危险因素，颈部和邻近保护区域之间的永久性色差异是SCC的独立显著危险因素。在纳入这些因素的模型中，到达年龄或移民身份和种族血统的影响仍然很重要。曾经有过痤疮和疣的历史是保护BCC和痤疮的历史是保护SCC。
The roles of ethnic origin, pigmentary traits, sun sensitivity and other cutaneous characteristics as risk factors for basal-cell carcinoma (BCC) and squamous-cell carcinoma (SCC) were examined in a case-control study of prevalent and incident cases of histopathologically confirmed skin cancers. Two hundred and twenty six confirmed cases of BCC, 45 of SCC and 1,015 controls with no lesions were identified in a population-based survey of skin cancer in 1987 in Geraldton, Western Australia. The risk of both cancers was higher in native-born Australians than in migrants. The risk of BCC decreased with increasing age at arrival in Australia. Southern European ancestry was strongly protective against BCC (for any southern European grandparents) and SCC (no case of SCC had any grandparents of southern European origin). Inability to tan was the strongest pigmentary risk factor for both BCC and SCC. Among factors that incorporated a measure of sun exposure as well as sun sensitivity, freckling on the arm in childhood was important for both cancers, the number of moles on the back was important for BCC, and forearm skin colour and having a permanent colour difference between the neck and adjacent protected areas were important for SCC. Among measures of sun damage to the skin, solar elastosis of the neck was a strong risk factor for both BCC and SCC, loss of fine texture of the skin of the back of the hands (as measured by cutaneous microtopography) was important for BCC and telangiectasia of the face for SCC. When all important variables for each cancer were examined together in a single model with age, sex, migrant status or age at arrival in Australia, and ethnicity, inability to tan, solar elastosis of the neck, and the number of moles on the back were independently significant risk factors for BCC and solar elastosis of the neck and having a permanent colour difference between the neck and adjacent protected areas were independently significant risk factors for SCC. The effects of age at arrival or migrant status and ethnic origin remained important in the models incorporating these factors. A history of ever having acne and a history of warts were protective for BCC and a history of acne was protective for SCC.