All-trans-retinoic acid and polyriboinosinoic:: polyribocytidylic acid cooperate to elevate anti-tetanus immunoglobulin G and immunoglobulin M responses in vitamin A-deficient Lewis rats and Balb/c mice
All-trans-retinoic acid and polyriboinosinoic:: polyribocytidylic acid cooperate to elevate anti-tetanus immunoglobulin G and immunoglobulin M responses in vitamin A-deficient Lewis rats and Balb/c mice
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DOI：
10.1017/s0029665100000756
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发表时间：
2000-11-01
影响因子：
7
通讯作者：
Ross, AC
中科院分区：
文献类型：
--
作者：
DeCicco, KL;Ross, AC
维生素A(VA)缺乏会损害对T细胞依赖抗原(如破伤风环状病毒)的抗体反应，但这种影响可以通过给予视黄醇或视黄酸(RA)逆转。为了测试RA和多聚核糖核糖核酸(PIC)是否能在VA缺乏时协同增加特异性免疫球蛋白(Ig)G和IgM的产生，用TT免疫大鼠和小鼠，并用全反式RA、PIC或它们的联合治疗。VA缺乏的大鼠产生低的初级和继发性抗破伤风免疫球蛋白应答(VA缺乏对照与VA充足对照P<；0.001)，尽管与VA充足对照大鼠相比，总免疫球蛋白略有升高。尽管单独使用RA可使VA缺乏时的抗体产生增加至对照水平，但RA与PIC联合使用可协同增强这些反应(RA和PIC组V.所有其他组P
Vitamin A (VA) deficiency compromises antibody responses to T-cell-dependent antigens such as tetanus toroid, but this effect can be reversed through administration of retinol or retinoic acid (RA). To test whether RA and polyriboinosinioc : polyribocytidylic acid (PIC), a known inducer of several forms of interferon (IFN), can cooperate to increase specific immunoglobulin (Ig)G and IgM production during VA deficiency, rats and mice were made VA-deficient, immunized with TT and treated with all-trans-RA, PIC or their combination. VA-deficient rats produced low primary and secondary anti-tetanus IgG responses (VA-deficient controls v. VA-sufficient controls P < 0.001), although total IgG was slightly elevated when compared with VA-sufficient control rats. Although RA administered alone elevated antibody production during VA deficiency to control levels, RA combined with PIC synergistically enhanced these responses (RA and PIC group v. all other groups P