Cholinergic Urticaria, a New Pathogenic Concept: Hypohidrosis due to Interference with the Delivery of Sweat to the Skin Surface
Cholinergic Urticaria, a New Pathogenic Concept: Hypohidrosis due to Interference with the Delivery of Sweat to the Skin Surface
复制标题
胆碱能性荨麻疹，一种新的致病概念：由于汗液输送到皮肤表面受到干扰而导致的少汗症
作者：
Hiromi Kobayashi;S. Aiba;T. Yamagishi;M. Tanita;M. Hara;H. Saito;H. Tagami
背景：乙酰胆碱被怀疑是胆碱能性荨麻疹（CU）的发病因素，但尚无确切证据。相反，有零星的报告CU与获得性全身性少汗症。我们最近检查了2例CU患者，我们注意到他们都存在广泛的少汗症，只发生在冬季。目的：在这2例患者中，由于肩关节浅表阻塞引起的获得性少汗被怀疑是原因。病例1和病例2均为22岁日本男性，冬季一感到热，就开始出现无汗症，身上出现大量红色斑疹。这些症状在夏天不再出现。方法：对患者皮损进行组织学观察，并进行CU激发试验。结果：两例患者均在运动后出现典型风团，确诊为CU。组织学研究显示，结果提示存在闭塞的表浅肩关节。结论：我们认为，这种由于浅表汗管闭塞引起的多汗症也可能在许多其他病因不明的CU患者中发挥作用，这些患者在冬季出汗不频繁时会加重。
Background: Acetylcholine has been suspected to be a pathogenetic factor for cholinergic urticaria (CU), without definite evidence. In contrast, there are scattered reports of CU associated with acquired generalized hypohidrosis. We have recently examined 2 patients with CU in both of whom we noticed the presence of extensive hypohidrosis that occurred only in winter. Objective: In these 2 patients, acquired hypohidrosis due to superficial obstruction of the acrosyringium was suspected as the cause. Both case 1, a 22-year-old Japanese man, and case 2, a 21-year-old Japanese man, began to have anhidrosis and numerous red macules on their body whenever they felt hot in winter. These symptoms ceased to appear in summer. Methods: We studied histologically their lesional skin in addition to provocation tests for CU. Results: The diagnosis of CU was confirmed by the provocation of typical wheals after physical exercise in both cases. Histological study revealed findings suggestive of the presence of occlusion of the superficial acrosyringium. Conclusion: We think that such a hypohidrosis due to occlusion of superficial sweat ducts may also play a role in many other patients with CU of unknown etiology that becomes exacerbated in winter when sweating is not a frequent event.
运动引起的过敏反应是胆碱能荨麻疹的表现。
DOI：
10.1016/0091-6749(81)90158-5
发表时间：
1981
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Kaplan,AP;Natbony,SF;Tawil,AP;Fruchter,L;Foster,M
通讯作者：
Foster,M
影响因子：
13.8
作者：
Sato,K;Ohtsuyama,M;Samman,G
通讯作者：
Samman,G