Design of a small animal MR compatible PET scanner
Design of a small animal MR compatible PET scanner
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一种小动物 MR 兼容 PET 扫描仪的设计
DOI：
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
K. Farahani
中科院分区：
文献类型：
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作者：
R. Slates;S. Cherry;A. Boutefnouchet;Y. Shao;M. Dahlbom;K. Farahani
采用蒙特-卡罗模拟和实验测量相结合的方法，作者设计了一种小动物MR兼容PET（McPET）扫描仪，用于小鼠和大鼠体内的同步PET和MR成像。该扫描仪由一个480个LSO晶体的环组成，该环排列在3层中，每层160个晶体。晶体尺寸为2/spl倍/3/spl倍/7.5 mm/sup 3/。这是基于2.5 mm的目标分辨率，并且模拟显示7.5 mm的深度足以在所需视场内提供该分辨率。11.2 cm的系统直径足以容纳定位在立体定向框架内的动物。每个晶体将通过2 mm直径的光纤耦合到位于主磁场外部的多通道PMT。通过50 cm的光纤，可以清楚地看到一个峰，测得的能量分辨率为25%。原型光纤连接器已经过测试，可增加系统的灵活性，光损耗仅为6%。所提出的系统将具有足够的分辨率和灵敏度，用于小动物的许多应用，并将成为第一个实用的装置，同时在体内成像与PET和MR。
Using a combination of Monte-Carlo simulations and experimental measurements the authors have designed a small animal MR compatible PET (McPET) scanner for simultaneous PET and MR imaging of mice and rats in vivo. The scanner consists of one ring of 480 LSO crystals arranged in 3 layers with 160 crystals per layer. The crystal dimensions are 2/spl times/3/spl times/7.5 mm/sup 3/. This was based on a target resolution of 2.5 mm and simulations showing that a depth of 7.5 mm was sufficient to provide this resolution across the desired field of view. The system diameter of 11.2 cm is large enough to accommodate the animal positioned inside a stereotactic frame. Each crystal will be coupled through 2 mm diameter optical fibers to multichannel PMT's which reside outside the main magnetic field. Through 50 cm of optical fiber, a photopeak is clearly seen and the measured energy resolution is 25%. Prototype optical fiber connectors have been tested to increase the flexibility of the system and result in a light loss of only 6%. The proposed system will have adequate resolution and sensitivity for a number of applications in small animals and will be the first practical device for simultaneous in vivo imaging with PET and MR.
DOI：
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发表时间：
1999-07
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
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作者：
A. Chatziioannou;S. Cherry;Y. Shao;R. Silverman;K. Meadors;T. Farquhar;Marjan Pedarsani;M. Phelps
通讯作者：
A. Chatziioannou;S. Cherry;Y. Shao;R. Silverman;K. Meadors;T. Farquhar;Marjan Pedarsani;M. Phelps