Are Isofurans and Neuroprostanes Increased After Subarachnoid Hemorrhage and Traumatic Brain Injury?
Are Isofurans and Neuroprostanes Increased After Subarachnoid Hemorrhage and Traumatic Brain Injury?
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DOI：
10.1089/ars.2011.4125
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发表时间：
2011-11-01
影响因子：
6.6
通讯作者：
Mori, Trevor A.
中科院分区：
文献类型：
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作者：
Corcoran, Tomas B.;Mas, Emilie;Mori, Trevor A.
目前用于评估蛛网膜下腔出血（aSAH）和创伤性脑损伤（TBI）后神经损伤的诊断工具区分能力较差。自由基与脑外伤后继发性损伤的病理生理学有关。我们在aSAH或严重TBI患者的两项病例对照研究中检查了脑脊液（CSF）氧化应激脂质标志物异呋喃（IsoFs）、F（4）-神经前列腺素（F（4）-NeuroPs）和F（2）-异前列腺素（F（2）-IsoPs）。aSAH（n = 18）或TBI（n = 18）患者的年龄和性别与单独的对照组相匹配。在损伤后24小时内收集患者的CSF样本。aSAH患者的CSF IsoF和F（4）-NeuroPs与对照组相比升高。在TBI患者中，IsoFs和F（4）-NeuroPs与对照组相比增加。与各自的对照组相比，aSAH患者的F（2）-IsoPs增加，但TBI患者的F（2）-IsoPs没有增加。CSF IsoF和F（4）-NeuroPs在灾难性中枢神经系统损伤后持续增加。这些结果表明，他们的测量可能会提高无意识的患者在神经系统护理的管理。抗氧化剂。氧化还原信号。15，2663-2667。
Current diagnostic tools to assess neurological injury after aneurysmal subarachnoid hemorrhage (aSAH) and traumatic brain injury (TBI) have poor discriminatory abilities. Free radicals are associated with the pathophysiology of secondary damage after brain trauma. We examined cerebrospinal fluid (CSF) lipid markers of oxidative stress, isofurans (IsoFs), F(4)-neuroprostanes (F(4)-NeuroPs), and F(2)-isoprostanes (F(2)-IsoPs), in two case-controlled studies in patients with aSAH or severe TBI. Patients with aSAH (n = 18) or TBI (n = 18) were age and gender matched with separate control groups. CSF samples were collected from patients within 24 h of the injury. CSF IsoFs and F(4)-NeuroPs were increased in aSAH patients compared with their controls. In TBI patients, IsoFs and F(4)-NeuroPs were increased compared with their controls. F(2)-IsoPs were increased in aSAH patients, but not in TBI patients, compared with their respective controls. CSF IsoFs and F(4)-NeuroPs are consistently increased after a catastrophic central nervous system injury. These results suggest their measurement may enhance the management of unconscious patients in neurological care. Antioxid. Redox Signal. 15, 2663-2667.