A comparison of Newtonian and non-Newtonian pulsatile blood rheology in carotid bifurcation through fluid solid interaction hemodynamic assessment based on experimental data
A comparison of Newtonian and non-Newtonian pulsatile blood rheology in carotid bifurcation through fluid solid interaction hemodynamic assessment based on experimental data
复制标题
基于实验数据的流固相互作用血流动力学评估颈动脉分叉处牛顿和非牛顿脉动血液流变学的比较
DOI：
10.1063/5.0094656
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发表时间：
2022
影响因子：
4.6
通讯作者：
H. Taghizadeh
中科院分区：
文献类型：
--
作者：
Milad Samaee;Ahmad Nooraeen;M. Tafazzoli;H. Taghizadeh
内皮细胞在动脉内稳态中起着至关重要的作用。除了生理风险因素外，脉动流引起的血流动力学参数的异常水平有助于动脉粥样硬化斑块的形成和发展。在这项研究中，我们使用一个实验装置来研究牛顿和非牛顿血液流动的血液动力学的人体颈动脉分叉的可变形模型。将实验模型的流量/压力脉冲输入流固耦合数值模型，得到两种流态下的相应血流动力学参数并进行比较。结果显示，当考虑到血流和压力的脉动性质时，两种流动方式之间存在明显差异，在交界处附近存在更明显的差异。非牛顿模型的速度剖面在回流过程中随着回流的增加而变得更加平坦。剪切应力波以及剪切相关参数，如振荡剪切指数，相对停留时间，涡度，以及壁应力和应变，也表明两种模型之间的显着差异。无论血流状态如何，结果显示与人类颈动脉分叉处，特别是颈动脉窦的临床结果具有良好的一致性。在分叉附近，剪应力的波动是明显的。在交界处周围，室壁脉动经历了正常脉冲跨度五倍的变化。从所提出的精确的颈动脉分叉模型获得的量化的血流动力学参数可以帮助实现技术解决方案，以调整这些参数的生物范围之外，并且避免动脉粥样硬化形成或治疗患病的动脉。
Endothelial cells play a crucial role in the arterial homeostasis. In addition to physiological risk factors, abnormal levels of hemodynamic parameters induced by the pulsatile flow contribute to atherosclerotic plaque formation and development. In this study, we used an experimental setup to study the hemodynamics of Newtonian and non-Newtonian blood flow on a deformable model of human carotid bifurcation. The flow/pressure pulses of the experimental model were fed into a fluid-structure interaction numerical model, and respective hemodynamic parameters were obtained and compared between the two flow regimes. Results revealed noticeable differences among the two flow regimes when the pulsatile nature of blood flow and pressure were considered, with more distinct differences near junction sites. Velocity profiles of the non-Newtonian model were more flattened with higher back flow during the diastole. The shear stress waves as well as shear-dependent parameters, such as oscillatory shear index, relative residence time, and vorticity, as well as wall stress and strain, also indicated significant differences among the two models. Regardless of flow regime, results showed a good agreement with clinical outcomes in human carotid bifurcation, especially the carotid sinus. Near the bifurcation, marked fluctuations of shear stress are evident. Around the junction site, wall pulsation experienced variations up to five times of the normal pulse span. The quantified hemodynamic parameters obtained from proposed accurate model of carotid bifurcation may help to achieve technological solutions to adjust the out of biological ranges of these parameters, and avoid atheroma formation or treat the diseased artery.